Results 51 to 60 of about 249,867 (244)

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Green Dixy E, Ihnat Michael A, Green, Dixy E., Satyendra S Shenoy, Shenoy Satyendra S, Green DE, Thorpe JE, Ceriello Antonio, Kamat CD, Ceriello, Antonio, Antonio Ceriello, Shenoy, Satyendra S, Dixy E Green, Kamat Chandrashekhar D, Linda A Warnke, Warnke, Linda A., Warnke Linda A, Shenoy SS, Chandrashekhar D Kamat, Michael A Ihnat, Warnke LA, Kamat, Chandrashekhar D., Ihnat, Michael A., Ihnat M.A., Thorpe, Jessica E, Thorpe Jessica E, Jessica E Thorpe   +26 more
core   +2 more sources

The Role of Reactive Oxygen Species in Muscle: Beneficial/Harmful [PDF]

, 2022
Introduction: Skeletal muscle produces moderate quantities of oxidant species, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), due to its contractile action, high oxygen consumption, and metabolic rate (RNS).
Zulfahmidah, Zulfahmidah, Safei, Imran, Imran Safei, Zulfahmidah Zulfahmidah   +3 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American heart association

, 2016
Reactive oxygen species and reactive nitrogen species are biological molecules that play important roles in cardiovascular physiology and contribute to disease initiation, progression, and severity. Because of their ephemeral nature and rapid reactivity,
Griendling, Kathy K., Harrison, David G., Dikalov, Sergey, Zweier, Jay L., Bhatnagar, Aruni, Touyz, Rhian M., Chilian, William, Yeong-Renn, Chen   +7 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Spectrophotometric Quantification of Reactive Oxygen, Nitrogen and Sulfur Species in Plant Samples

, 2017
Reactive oxygen, nitrogen and sulfur species are key signalling molecules involved in multiple physiological processes that can be examined in qualitative and quantitative manners.
Fotopoulos, Vasileios, Savvides, Andreas M., Egli C. Georgiadou, Georgiadou, Egli C., Andreas Savvides, Antoniou, Chrystalla, Vasileios Fotopoulos, Chrystalla Antoniou   +7 more
core   +1 more source

Feed-derived volatile basic nitrogen increases reactive oxygen species production of blood leukocytes in lactating dairy cows. [PDF]

, 2017
The present study investigated over 9 months the changes of fermentative quality of total mixed rations (TMR) containing grass silage (GS) as a major component, associated with changes in the volatile basic nitrogen (VBN) levels in an experimental dairy ...
Bruckmaier, Rupert, Miyamoto, Akio, Tsunoda, Ei, Kawashima, Chiho, Kida, Katsuya, Gross, Josef Johann, Gross JJ, Bruckmaier RM, Miyamoto A, Kida K, Tsunoda E, Kawashima C   +11 more
core   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Extracellular production of reactive oxygen species in response to abiotic stress in seeds [PDF]

, 2009
Reactive oxygen species (ROS), such as superoxide (O2 •‾), hydrogen peroxide (H2O2), singlet oxygen (1O2) and the hydroxyl radical (•OH) can damage essential biomolecules including nucleic acids, proteins and lipids, causing damage to various ...
Roach, T.
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