Results 261 to 270 of about 857,471 (304)
Some of the next articles are maybe not open access.
Ezetimibe and Reactive Oxygen Species
Current Vascular Pharmacology, 2011Ezetimibe is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia. Statin, 3-hydroxy-3 methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, is an inhibitor of cholesterol synthesis. Statin is the first-choice drug to reduce low-density lipoprotein (LDL)-cholesterol for patients with ...
Minako, Yamaoka-Tojo +4 more
openaire +2 more sources
Glucose and reactive oxygen species
Current Opinion in Clinical Nutrition and Metabolic Care, 2002This review aims at presenting new concepts of glucose-induced damage in diabetes via an increased production of oxygen free radicals.Reactive oxygen species modulate various biological functions by stimulating transduction signals, some of which are involved in diabetes pathogenesis and complications.Diabetes is characterized by high glucose ...
openaire +2 more sources
Reactive oxygen species in hypertension
Nature Reviews CardiologyHypertension is a leading risk factor for stroke, heart disease and chronic kidney disease. Multiple interacting factors and organ systems increase blood pressure and cause target-organ damage. Among the many molecular elements involved in the development of hypertension are reactive oxygen species (ROS), which influence cellular processes in systems ...
Livia L. Camargo +3 more
openaire +2 more sources
Oxygen, Reactive Oxygen Species and Tissue Damage
Current Pharmaceutical Design, 2004The diatomic molecule of oxygen contains two uncoupled electrons and can therefore undergo reduction, yielding several different oxygen metabolites, which are collectively called Reactive Oxygen Species or ROS. They are invariably produced in aerobic environments through a variety of mechanisms, which include electron "leakage" during biologic ...
BERGAMINI, Carlo +3 more
openaire +2 more sources
Infection and reactive oxygen species
Andrologia, 2009In previous years the physiologic and pathophysiologic significance of reactive oxygen species (ROS) on sperm function has been recognized. The impact of ROS during the invasion, adhesion and multiplication of microorganisms in the male genital tract are largely unknown.
openaire +2 more sources
Reactive Oxygen Species as Mediators in Asthma
Pulmonary Pharmacology & Therapeutics, 2001This review describes production and effects of reactive oxygen species (ROS) on airway function. ROS are important in many physiological processes but can also have detrimental effects on airway cells and tissues when produced in high quantities or during the absence of sufficient amounts of anti-oxidants.
Henricks, P.A.J., Nijkamp, F.P.
openaire +3 more sources
Reactive oxygen species in mechanotransduction
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2004a randomized clinical trial by the Acute Respiratory Distress Syndrome Network ([1][1]) demonstrated a 22% reduction in mortality in patients by reducing the tidal volume for mechanical ventilation from the conventional setting of 12 ml/kg to a lower setting of 6 ml/kg.
openaire +2 more sources
Reactive Oxygen Species Signaling in Plants
Antioxidants & Redox Signaling, 2006The evolution of aerobic metabolism such as respiration and photosynthesis resulted in the generation of reactive oxygen species (ROS). A common property of all ROS types is that they can cause oxidative damage to proteins, DNA, and lipids. This toxicity of ROS explains the evolution of complex arrays of nonenzymatic and enzymatic detoxification ...
Pitzschke, Andrea +2 more
openaire +3 more sources
Oxidative Stress and Reactive Oxygen Species
2005This article discusses different aspects concerning classification/nomenclature, biochemical properties and pathophysiological roles of reactive oxygen species (ROS) which are pivotal to interpret the concept of oxidative stress. In vitro studies in both the prokaryotes and eukaryotes clearly demonstrate that exogenous or constitutive and inducible ...
GALLI, Francesco +5 more
openaire +3 more sources