Results 1 to 10 of about 233,564 (300)

Marburg virus-like particles by co-expression of glycoprotein and matrix protein in insect cells induces immune responses in mice

Virology Journal, 2017
Background Marburg virus (MARV) causes severe haemorrhagic fever in humans and nonhuman primates and has a high mortality rate. However, effective drugs or licensed vaccines are not currently available to control the outbreak and spread of this disease ...
Weiwei Gai, Xuexing Zheng, Chong Wang, Hualei Wang, Yongkun Zhao, Qi Wang, Gary Wong, Weijiao Zhang, Na Feng, Boning Qiu, Hang Chi, Nan Li, Tiecheng Wang, Yuwei Gao, Junjie Shan, Songtao Yang, Xianzhu Xia   +16 more
doaj   +1 more source

A saposin-lipoprotein nanoparticle system for membrane proteins. [PDF]

A limiting factor in membrane protein research is the ability to solubilize and stabilize such proteins. Detergents are used most often for solubilizing membrane proteins, but they are associated with protein instability and poor compatibility with ...
Armache, Jean-Paul, Briggs, John AG, Cheng, Yifan, Flayhan, Ali, Frauenfeld, Jens, Garoff, Henrik, Guettou, Fatma, Jegerschöld, Caroline, Löving, Robin, Löw, Christian, Moberg, Per, Nordlund, Pär, Sonnen, Andreas F-P, Zhu, Lin   +13 more
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Virus-Like Particle Vaccination Protects Nonhuman Primates from Lethal Aerosol Exposure with Marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges)

Viruses, 2016
Marburg virus (MARV) was the first filovirus to be identified following an outbreak of viral hemorrhagic fever disease in Marburg, Germany in 1967. Due to several factors inherent to filoviruses, they are considered a potential bioweapon that could be ...
John M. Dye, Kelly L. Warfield, Jay B. Wells, Robert C. Unfer, Sergey Shulenin, Hong Vu, Donald K. Nichols, M. Javad Aman, Sina Bavari   +8 more
doaj   +1 more source

Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the immunogenicity of rabies virus-like particles in mice and dogs

Frontiers in Microbiology, 2015
Rabies remains an important worldwide public health threat, so safe, effective and affordable vaccines are still being sought. Virus-like particle (VLP)-based vaccines targeting various viral pathogens have been successfully produced, licensed and ...
Yinglin eQi, Yinglin eQi, Hongtao eKang, Hongtao eKang, Xuexing eZheng, Hualei eWang, Yuwei eGao, Songtao eYang, Xianzhu eXia   +8 more
doaj   +1 more source

Comparative Molecular Biology Approaches for the Production of Poliovirus Virus-Like Particles Using Pichia pastoris

mSphere, 2020
For enteroviruses such as poliovirus (PV), empty capsids, which are antigenically indistinguishable from mature virions, are produced naturally during viral infection.
Lee Sherry, Keith Grehan, Joseph S. Snowden, Michael L. Knight, Oluwapelumi O. Adeyemi, David J. Rowlands, Nicola J. Stonehouse   +6 more
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Tomato spotted wilt virus glycoproteins induce the formation of endoplasmic reticulum- and Golgi-derived pleomorphic membrane structures in plant cells [PDF]

Tomato spotted wilt virus (TSWV) particles are spherical and enveloped, an uncommon feature among plant infecting viruses. Previous studies have shown that virus particle formation involves the enwrapment of ribonucleoproteins with viral glycoprotein ...
Denecke, J., Foresti, O., Goldbach, R.W., Kormelink, R.J.M., Ribeiro, D.M.O.G., Wellink, J.   +5 more
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Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end [PDF]

Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical.
A Ali, A Harris, A Moeller, A Smirnov Yu, BE Eddy, BJ Chen, C Loney, C Scholtissek, CJ Elleman, CM Chu, Colin Loney, D McGeoch, David Bhella, David Jackson, DN Mastronarde, E Fournier, Frazer J. Rixon, GL Ada, I Archetti, JR Gog, JR Kremer, JS Rossman, JS Rossman, KB Renegar, L Hoyle, L Liljeroos, LJ Calder, LM Burleigh, M Adrian, P Palese, PC Roberts, PC Roberts, Peter Palese, R Arranz, RA Lamb, RA Lamb, RW Compans, RW Ruigrok, Swetha Vijayakrishnan, T Noda, T Noda, TA Bharat, V Doceul, Worawit Suphamungmee, Y Fujii, Y Geng   +45 more
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Immunogenicity assessment for vidutolimod: a risk-driven approach for a simplified 1-tiered, singlicate anti-drug antibody testing strategy

Frontiers in Immunology
The bioanalytical strategy for a therapeutic should be driven by the overall immunogenicity risk of the molecule. Vidutolimod, a virus-like particle therapeutic, is being developed with a unique mechanism of action that requires the generation of a ...
Jenny L. Valentine, Stacey Shank, Lisette M. Fred Lucena, Zhiqiang Wang, Colleen McLaughlin Stern, Byung Chul Kim, Kun Lu, Saileta Prabhu, Michael A. Partridge   +8 more
doaj   +1 more source

The role of influenza neuraminidase transmembrane domain on budding and virus morphology [PDF]

Influenza A virus neuraminidase (NA), a type II transmembrane glycoprotein plays a role in the cleavage of sialic acids and facilitating the release of mature virions from the surface of infected cells. NA has also previously been shown to play a role in
Roddy, Scott, Edward
core  

A method for molecular dynamics on curved surfaces [PDF]

Dynamics simulations of constrained particles can greatly aid in understanding the temporal and spatial evolution of biological processes such as lateral transport along membranes and self-assembly of viruses.
Kusters, Remy, Paquay, Stefan
core   +1 more source