Results 41 to 50 of about 6,680,139 (200)

Norwalk virus-like particles as vaccines [PDF]

Expert Review of Vaccines, 2010
Noroviruses (NoV) cause the great majority of epidemic nonbacterial gastroenteritis in humans. Expression of the capsid protein in recombinant systems, including insect and plant cells, yields assembly of virus-like particles (VLPs) that mimic the antigenic structure of authentic virions, and are relatively acid- and heat-stable.
Melissa, Herbst-Kralovetz, Hugh S, Mason, Qiang, Chen   +2 more
openaire   +2 more sources

Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma. [PDF]

, 2014
UNLABELLED Adenovirus dodecahedron (Dd), a nanoparticulate proteinaceous biodegradable virus-like particle (VLP), was used as a vector for delivery of an oncogene inhibitor to hepatocellular carcinoma (HCC) rat orthotopic model.
Kowalska, Joanna, Piguet, Anne Christine, Piguet, Anne-Christine, Zochowska, Monika, Szolajska, Ewa, Chroboczek, Jadwiga, Jemielity, Jacek, Dufour, Jean-François   +7 more
core   +2 more sources

The structural basis for the integrity of adenovirus Ad3 dodecahedron [PDF]

, 2012
During the viral life cycle adenoviruses produce excess capsid proteins. Human adenovirus serotype 3 (Ad3) synthesizes predominantly an excess of free pentons, the complexes of pentameric penton base and trimeric fiber proteins, which are responsible for
Fender, Pascal, Monika Zochowska (134637), Jean-Pierre Andrieu, Ewa Szolajska (134629), Stephen Cusack (134664), Burmeister, Wim P, Pascal Fender (132764), Szolajska, Ewa, Pascal Fender, Nerlo, Barbara, Burmeister, Wim P., Igor Andreev, Wim P. Burmeister (134634), Wim P Burmeister, Guy Schoehn, Jadwiga Chroboczek (134668), Andreev, Igor, Naskalska, Antonina, Stephen Cusack, Chroboczek, Jadwiga, Barbara Nerlo (134643), Ewa Szolajska, Chloe Zubieta (134662), Barbara Nerlo, Igor Andreev (134649), Andrieu, Jean-Pierre, Jadwiga Chroboczek, Chloe Zubieta, Monika Zochowska, Zochowska, Monika, Cusack, Stephen, Jean-Pierre Andrieu (134655), Schoehn, Guy, Antonina Naskalska, Guy Schoehn (27525), Zubieta, Chloe, Antonina Naskalska (134660)   +36 more
core   +3 more sources

Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation.

PLoS ONE, 2014
Identifying safe and effective adjuvants is critical for the advanced development of protein-based vaccines. Pattern recognition receptor (PRR) agonists are increasingly being explored as potential adjuvants, but there is concern that the efficacy of ...
Karen A O Martins, Jesse T Steffens, Sean A van Tongeren, Jay B Wells, Alison A Bergeron, Samuel P Dickson, John M Dye, Andres M Salazar, Sina Bavari   +8 more
doaj   +1 more source

The 5th Virus-like Particle and Nano-Particle Vaccines (VLPNPV) conference.

, 2019
Virus-like Particles (VLPs) and Nano-Particles (NPs) are promising vaccine platforms that have led to the successful development of commercially available vaccines.
Engeroff, Paul, Bachmann, Martin, Paul Engeroff, Martin F. Bachmann   +3 more
core   +1 more source

Design Concepts of Virus-Like Particle-Based HIV-1 Vaccines

Frontiers in Immunology, 2020
Prophylactic vaccines remain the best approach for controlling the human immunodeficiency virus-1 (HIV-1) transmission. Despite the limited efficacy of the RV144 trial in Thailand, there is still no vaccine candidate that has been proven successful ...
Chun-Wei Chen, Narcís Saubi, Narcís Saubi, Joan Joseph-Munné, Joan Joseph-Munné, Joan Joseph-Munné   +5 more
doaj   +1 more source

Recombinant Virus-like Particles of Human Parvovirus B19 with the Internal Location of VP1 Unique Region Produced by Hansenula polymorpha

Viruses, 2022
Human parvovirus B19 (HPV B19) is pathogenic to human, which can cause fifth disease, transient aplastic crisis, arthritis, myocarditis, autoimmune disorders, hydrops fetalis, and so on.
Shuai Shao, Qingqing Wang, Yuqin Jin, Xuefeng Zhang, Zhaoming Liu, Shi Chen, Hailan Wu, Sensen Yang, Fang Tang, Jiguo Su, Yu Liang, Jing Zhang, Qiming Li   +12 more
doaj   +1 more source

Effective chikungunya virus-like particle vaccine produced in insect cells. [PDF]

PLoS Neglected Tropical Diseases, 2013
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful
Stefan W Metz, Joy Gardner, Corinne Geertsema, Thuy T Le, Lucas Goh, Just M Vlak, Andreas Suhrbier, Gorben P Pijlman   +7 more
doaj   +1 more source

A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

International Journal of Nanomedicine, 2012
Wei Shao1, Arghya Paul1, Sana Abbasi1, Parminder S Chahal2, Jimmy A Mena2, Johnny Montes2, Amine Kamen2, Satya Prakash11Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs ...
Shao W, Paul A, Abbasi S, Chahal PS, Mena JA, Montes J, Kamen A, Prakash S   +7 more
doaj  

Neuraminidase in Virus-like Particles Contributes to the Protection against High Dose of Avian Influenza Virus Challenge Infection

Pathogens, 2021
Neuraminidase is an important target for influenza vaccination. In this study, we generated avian influenza VLPs, expressing hemagglutinin (HA), neuraminidase (NA), HA and NA co-expressed (HANA), to evaluate the protective role of NA against a high ...
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan   +8 more
doaj   +1 more source