Results 51 to 60 of about 6,680,139 (200)

The role of influenza neuraminidase transmembrane domain on budding and virus morphology [PDF]

, 2014
Influenza A virus neuraminidase (NA), a type II transmembrane glycoprotein plays a role in the cleavage of sialic acids and facilitating the release of mature virions from the surface of infected cells. NA has also previously been shown to play a role in
Roddy, Scott, Edward
core  

RNA Phage VLP-Based Vaccine Platforms

Pharmaceuticals, 2021
Virus-like particles from a variety of RNA bacteriophages have turned out to be useful platforms for delivery of vaccine antigens in a highly immunogenic format.
David S. Peabody, Julianne Peabody, Steven B. Bradfute, Bryce Chackerian   +3 more
doaj   +1 more source

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

An infectious virus-like particle built on a programmable icosahedral DNA framework [PDF]

, 2022
Viral genomes can be compressed into a near spherical nanochamber to form infected particles. In order to mimic the virus morphology and packaging behavior, we invented a programmable icosahedral DNA nanoframe with enhanced rigidity and encapsulated the ...
Qian, Shi, Wei, Wang, Yunyun, Xu, Andrew, Ward, Yang, Yang, Yuhe, Yang   +5 more
core   +1 more source

Marburg virus-like particles by co-expression of glycoprotein and matrix protein in insect cells induces immune responses in mice

Virology Journal, 2017
Background Marburg virus (MARV) causes severe haemorrhagic fever in humans and nonhuman primates and has a high mortality rate. However, effective drugs or licensed vaccines are not currently available to control the outbreak and spread of this disease ...
Weiwei Gai, Xuexing Zheng, Chong Wang, Hualei Wang, Yongkun Zhao, Qi Wang, Gary Wong, Weijiao Zhang, Na Feng, Boning Qiu, Hang Chi, Nan Li, Tiecheng Wang, Yuwei Gao, Junjie Shan, Songtao Yang, Xianzhu Xia   +16 more
doaj   +1 more source

Four nudivirus core genes present in the genome of Venturia canescens are required for virus-like particle formation and prevention of encapsulation of parasitoid wasp eggs

Journal of Virology
Venturia canescens is a parasitoid wasp that harbors a domesticated endogenous virus (DEV) and parasitizes host insects like Ephestia kuehniella. The V. canescens DEV evolved from an alphanudivirus and produces virus-like particles (VLPs) in females that
Meng Mao, Corinne M. Stouthamer, Ange Lorenzi, Michael R. Strand, Gaelen R. Burke   +4 more
doaj   +1 more source

Virus-Like Particle Vaccination Protects Nonhuman Primates from Lethal Aerosol Exposure with Marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges)

Viruses, 2016
Marburg virus (MARV) was the first filovirus to be identified following an outbreak of viral hemorrhagic fever disease in Marburg, Germany in 1967. Due to several factors inherent to filoviruses, they are considered a potential bioweapon that could be ...
John M. Dye, Kelly L. Warfield, Jay B. Wells, Robert C. Unfer, Sergey Shulenin, Hong Vu, Donald K. Nichols, M. Javad Aman, Sina Bavari   +8 more
doaj   +1 more source

Virus-like particles as vaccine adjuvants

Molecular Biotechnology, 2001
Virus-like particles (VLPs) consist of one or more viral coat proteins that assemble into particles. They can be taken up by antigen presenting cells (APC), peptides derived from them are presented on MHC class I molecules at the cell surface, and thereby prime a CD8+ T cell response, either against the particle-forming protein itself (such as ...
openaire   +3 more sources

Distribution of TT virus (TTV), TTV-like minivirus, and related viruses in humans and nonhuman primates [PDF]

, 2003
TT virus (TTV) and TTV-like minivirus (TLMV) are small DNA viruses with single-stranded, closed circular, antisense genomes infecting man. Despite their extreme sequence heterogeneity (>50%), a highly conserved region in the untranslated region (UTR ...
Thom, K, Lewis, J.C.M, Lewis, J C M, Morrison, C, Simmonds, P   +4 more
core   +1 more source

Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the immunogenicity of rabies virus-like particles in mice and dogs

Frontiers in Microbiology, 2015
Rabies remains an important worldwide public health threat, so safe, effective and affordable vaccines are still being sought. Virus-like particle (VLP)-based vaccines targeting various viral pathogens have been successfully produced, licensed and ...
Yinglin eQi, Yinglin eQi, Hongtao eKang, Hongtao eKang, Xuexing eZheng, Hualei eWang, Yuwei eGao, Songtao eYang, Xianzhu eXia   +8 more
doaj   +1 more source