Results 51 to 60 of about 231,821 (301)

Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation.

PLoS ONE, 2014
Identifying safe and effective adjuvants is critical for the advanced development of protein-based vaccines. Pattern recognition receptor (PRR) agonists are increasingly being explored as potential adjuvants, but there is concern that the efficacy of ...
Karen A O Martins, Jesse T Steffens, Sean A van Tongeren, Jay B Wells, Alison A Bergeron, Samuel P Dickson, John M Dye, Andres M Salazar, Sina Bavari   +8 more
doaj   +1 more source

Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles [PDF]

, 2015
We present a new theory for modeling forced indentation spectral lineshapes of biological particles, which considers non-linear Hertzian deformation due to an indenter-particle physical contact and bending deformations of curved beams modeling the ...
Gijs J L Wuite, Joost Snijder, Kenneth A Marx, Olga Kononova, Valeri Barsegov, Wouter H Roos, Yaroslav Kholodov   +6 more
core   +4 more sources

Characterization of Chikungunya Virus-Like Particles

PLoS ONE, 2014
El virus Chikungunya (CHIKV) se está convirtiendo en una preocupación mundial debido al creciente número de brotes en todo el mundo y la ausencia de cualquier vacuna o tratamiento específico contra el CHIKV. Las partículas similares a virus (VLP) son proteínas multiestructuradas que imitan la organización y conformación de los virus nativos, pero ...
Nitchakarn Noranate, Naokazu Takeda, Prukswan Chetanachan, Pathompong Sittisaman, Atchareeya A-Nuegoonpipat, Surapee Anantapreecha   +5 more
openaire   +4 more sources

Radiation Brightening from Virus-like Particles [PDF]

ACS Nano, 2019
Concentration quenching is a well-known challenge in many fluorescence imaging applications. Here we show that the optical emission from hundreds of chromophores confined onto the surface of a virus particle 28 nm diameter can be recovered under pulsed irradiation.
Irina B. Tsvetkova, Arathi Anil Sushma, Joseph Che-Yen Wang, William L. Schaich, Bogdan Dragnea   +4 more
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Next generation designer virus-like particle vaccines for dengue

Expert Review of Vaccines, 2019
Introduction: A safe and efficacious vaccine for dengue continues to be an unmet public health need. The recent licensing of a dengue vaccine (Dengvaxia) developed by Sanofi has brought to the fore the safety issue of vaccine-induced infection ...
Rahul Shukla, Viswanathan Ramasamy, Ravi Kant Rajpoot, Upasana Arora, Ankur Poddar, Richa Ahuja, Hemalatha Beesetti, Sathyamangalam Swaminathan, Navin Khanna   +8 more
doaj   +1 more source

Virus-like particles—universal molecular toolboxes

Current Opinion in Biotechnology, 2007
Virus-like particles (VLPs) are highly organised spheres that self-assemble from virus-derived structural antigens. These stable and versatile subviral particles possess excellent adjuvant properties capable of inducing innate and cognate immune responses.
Ludwig, Christine, Wagner, Ralf
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

International Journal of Nanomedicine, 2012
Wei Shao1, Arghya Paul1, Sana Abbasi1, Parminder S Chahal2, Jimmy A Mena2, Johnny Montes2, Amine Kamen2, Satya Prakash11Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs ...
Shao W, Paul A, Abbasi S, Chahal PS, Mena JA, Montes J, Kamen A, Prakash S   +7 more
doaj  

Effective chikungunya virus-like particle vaccine produced in insect cells. [PDF]

PLoS Neglected Tropical Diseases, 2013
The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful
Stefan W Metz, Joy Gardner, Corinne Geertsema, Thuy T Le, Lucas Goh, Just M Vlak, Andreas Suhrbier, Gorben P Pijlman   +7 more
doaj   +1 more source