Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike [PDF]
The genus <i>Orthobunyavirus</i> within the family <i>Bunyaviridae</i> constitutes an expanding group of emerging viruses, which threaten human and animal health.
McLees, A. +42 more
core +1 more source
Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity [PDF]
Foot-and-mouth disease virus (FMDV) is a significant economically and distributed globally pathogen of Artiodactyla. Current vaccines are chemically inactivated whole virus particles that require large-scale virus growth in strict bio-containment with ...
Owens, Ray +50 more
core +1 more source
Virus-like particle vaccine protects against 2009 H1N1 pandemic influenza virus in mice. [PDF]
The 2009 influenza pandemic and shortages in vaccine supplies worldwide underscore the need for new approaches to develop more effective vaccines.We generated influenza virus-like particles (VLPs) containing proteins derived from the A/California/04/2009
Fu-Shi Quan +3 more
doaj +1 more source
Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis [PDF]
Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are
Killip, M. J. +14 more
core +1 more source
Membrane Interactions of Virus-like Mesoporous Silica Nanoparticles [PDF]
In the present study, we investigated lipid membrane interactions of silica nanoparticles as carriers for the antimicrobial peptide LL-37 (LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES).
Browning, Kathryn L. +25 more
core +1 more source
Escherichia coli-derived virus-like particles in vaccine development
Recombinant virus-like particle-based vaccines are composed of viral structural proteins and mimic authentic native viruses but are devoid of viral genetic materials. They are the active components in highly safe and effective vaccines for the prevention
Xiaofen Huang +4 more
doaj +1 more source
Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma. [PDF]
UNLABELLED Adenovirus dodecahedron (Dd), a nanoparticulate proteinaceous biodegradable virus-like particle (VLP), was used as a vector for delivery of an oncogene inhibitor to hepatocellular carcinoma (HCC) rat orthotopic model.
Kowalska, Joanna +7 more
core +2 more sources
Hepatitis B Virus (HBV) Subviral Particles as Protective Vaccines and Vaccine Platforms
Hepatitis B remains one of the major global health problems more than 40 years after the identification of human hepatitis B virus (HBV) as the causative agent.
Joan Kha-Tu Ho +2 more
doaj +1 more source
Multiplex Human Papillomavirus L1L2 virus-like particle antibody binding assay
A variety of in vitro techniques are available to estimate the level of antibodies present in human serum samples. Such tests are highly specific and are used to determine prior exposure to a pathogen or to estimate the magnitude, breadth and durability ...
Kavita Panwar +7 more
doaj +1 more source
The structural basis for the integrity of adenovirus Ad3 dodecahedron [PDF]
During the viral life cycle adenoviruses produce excess capsid proteins. Human adenovirus serotype 3 (Ad3) synthesizes predominantly an excess of free pentons, the complexes of pentameric penton base and trimeric fiber proteins, which are responsible for
Fender, Pascal +36 more
core +1 more source

