Results 31 to 40 of about 233,564 (300)

Versatile virus-like particle carrier for epitope based vaccines. [PDF]

PLoS ONE, 2010
BACKGROUND: Recombinant proteins and in particular single domains or peptides are often poorly immunogenic unless conjugated to a carrier protein. Virus-like-particles are a very efficient means to confer high immunogenicity to antigens.
Alain C Tissot, Regina Renhofa, Nicole Schmitz, Indulis Cielens, Edwin Meijerink, Velta Ose, Gary T Jennings, Philippe Saudan, Paul Pumpens, Martin F Bachmann   +9 more
doaj   +1 more source

Identification of Novel Adjuvants for Ebola Virus-Like Particle Vaccine

Vaccines, 2020
Ebola virus disease is a severe disease, often fatal, with a mortality rate of up to 90%. Presently, effective treatment and safe prevention options for Ebola virus disease are not available. Therefore, there is an urgent need to develop control measures
Huapeng Feng, Sumiho Nakatsu, Tiago Jose da Silva Lopes, Masaki Imai, Seiya Yamayoshi, Makoto Yamashita, Tokiko Watanabe, Yoshihiro Kawaoka   +7 more
doaj   +1 more source

Virus-Like Particle Production in Atmospheric Eubacteria Isolates

Atmosphere, 2019
Culturable eubacterial isolates were collected at various altitudes in Earth’s atmosphere, including ~1.5 m above ground in Tallahassee, FL, USA; ~10.0 m above sea level over the mid-Atlantic ridge (~15° N); ~20 km above ground over the ...
Nuria Teigell-Perez, Cristina Gonzalez-Martin, Basilio Valladares, David J. Smith, Dale W. Griffin   +4 more
doaj   +1 more source

A Novel Recombinant Virus-Like Particles Displaying B and T Cell Epitopes of Japanese Encephalitis Virus Offers Protective Immunity in Mice and Guinea Pigs

Vaccines, 2021
Virus-like particles (VLPs) are non-replicative vectors for the delivery of heterologous epitopes and are considered one of the most potent inducers of cellular and humoral immune responses in mice and guinea pigs.
Muhammad Naveed Anwar, Chunying Jiang, Di Di, Junjie Zhang, Shuang Guo, Xin Wang, Muddassar Hameed, Abdul Wahaab, Donghua Shao, Zongjie Li, Ke Liu, Beibei Li, Yafeng Qiu, Zhiyong Ma, Jianchao Wei   +14 more
doaj   +1 more source

Virus-Like Particle, Liposome, and Polymeric Particle-Based Vaccines against HIV-1

Frontiers in Immunology, 2018
It is acknowledged that vaccines remain the best hope for eliminating the HIV-1 epidemic. However, the failure to produce effective vaccine immunogens and the inability of conventional delivery strategies to elicit the desired immune responses remains a ...
Yong Gao, Chanuka Wijewardhana, Jamie F. S. Mann   +2 more
doaj   +1 more source

A Virus-Like Particle-Based Vaccine Candidate against the Tick-Borne Powassan Virus Induces Neutralizing Antibodies in a Mouse Model

Pathogens, 2021
Powassan virus (POWV) is a tick-borne flavivirus circulating in North America and the Russian Far East that can cause severe neuroinvasive diseases, including encephalitis, meningitis, and meningoencephalitis.
Velasco Cimica, Sahar Saleem, Emily Matuczinski, Debra Adams-Fish, Conor McMahon, Sujatha Rashid, Timothy T. Stedman   +6 more
doaj   +1 more source

The 5th virus-like particle and nano-particle vaccines (VLPNPV) conference

Expert Review of Vaccines, 2019
Virus-like particles (VLPs) and nano-particles (NPs) are promising vaccine platforms that have led to the successful development of commercially available vaccines.
Paul Engeroff, Martin F. Bachmann
doaj   +1 more source

Escherichia coli-derived virus-like particles in vaccine development

npj Vaccines, 2017
Recombinant virus-like particle-based vaccines are composed of viral structural proteins and mimic authentic native viruses but are devoid of viral genetic materials. They are the active components in highly safe and effective vaccines for the prevention
Xiaofen Huang, Xin Wang, Jun Zhang, Ningshao Xia, Qinjian Zhao   +4 more
doaj   +1 more source

Virus-like particle vaccine protects against 2009 H1N1 pandemic influenza virus in mice. [PDF]

PLoS ONE, 2010
The 2009 influenza pandemic and shortages in vaccine supplies worldwide underscore the need for new approaches to develop more effective vaccines.We generated influenza virus-like particles (VLPs) containing proteins derived from the A/California/04/2009
Fu-Shi Quan, Aswani Vunnava, Richard W Compans, Sang-Moo Kang   +3 more
doaj   +1 more source

The potential for reassortment between Oropouche and Schmallenberg Orthobunyaviruses [PDF]

A number of viruses within the Peribunyaviridae family are naturally occurring reassortants, a common phenomenon for segmented viruses. Using a minigenome-reporter and virus-like particle (VLP) production assay, we have accessed the potential of ...
Elliott, Richard M., Olszanski Acrani, Gustavo, Shi, Xiaohong, Tilston-Lunel, Natasha L.   +3 more
core   +1 more source