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Virus-like particle vaccines: immunology and formulation for clinical translation

Expert Review of Vaccines, 2018
Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation from laboratory models, to routine clinical administration. While some VLP vaccines thrive and are readily adopted into the vaccination schedule, others are
Braeden Donaldson, Zabeen Lateef, Greg F. Walker, Sarah L. Young, Vernon K. Ward   +4 more
doaj   +2 more sources

Self diffusion of particles in complex fluids: temporary cages and permanent barriers [PDF]

, 2008
We study the self diffusion of individual particles in dense (non-)uniform complex fluids within dynamic density functional theory and explicitly account for their coupling to the temporally fluctuating background particles. Applying the formalism to rod-
H. Risken, J.-P. Hansen, Marjolein Dijkstra, Markus Bier, P.-G. de Gennes, Paul van der Schoot, René van Roij   +6 more
core   +5 more sources

Advancing usability of an influenza hemagglutinin virus-like particle vaccine expressing a chimeric cytokine

Virology Journal, 2023
Vaccine efficacy of conventional influenza vaccines depend on the antigenic similarity between the selected vaccine strain and annual epidemic strain. Since the influenza virus evolves yearly, a vaccine which is independent from viral antigenic mutation ...
Toshifumi Imagawa, Youta Arasaki, Kenichi Maegawa, Shigeo Sugita, Kuniaki Nerome   +4 more
doaj   +1 more source

Virus-like Particle Vaccines and Platforms for Vaccine Development

Viruses, 2023
Virus-like particles (VLPs) have gained a lot of interest within the past two decades. The use of VLP-based vaccines to protect against three infectious agents—hepatitis B virus, human papillomavirus, and hepatitis E virus—has been approved; they are ...
Milad Kheirvari, Hong Liu, Ebenezer Tumban   +2 more
doaj   +1 more source

The potential for reassortment between Oropouche and Schmallenberg Orthobunyaviruses [PDF]

, 2017
A number of viruses within the Peribunyaviridae family are naturally occurring reassortants, a common phenomenon for segmented viruses. Using a minigenome-reporter and virus-like particle (VLP) production assay, we have accessed the potential of ...
Elliott, Richard M., Olszanski Acrani, Gustavo, Shi, Xiaohong, Tilston-Lunel, Natasha L.   +3 more
core   +1 more source

Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]

, 2016
There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico, Fiers, Walter, Saelens, Xavier, Schepens, Bert, Schotsaert, Michael, Smet, Anouk, Stegalkina, Svetlana, Vanderschaeghe, Dieter, Vogel, Thorsten U, Ysenbaert, Tine   +9 more
core   +2 more sources

Epitope-Specific Anti-hCG Vaccines on a Virus Like Particle Platform.

PLoS ONE, 2015
The possibility of a contraceptive vaccine targeting human chorionic gonadotropin has long been recognized, but never fully realized. Here we describe an epitope-specific approach based on immunogenic display of hCG-derived peptides on virus-like ...
Jerri Caldeira, Jeremiah Bustos, Julianne Peabody, Bryce Chackerian, David S Peabody   +4 more
doaj   +1 more source

The Immunogenicity of Capsid-Like Particle Vaccines in Combination with Different Adjuvants Using Different Routes of Administration

Vaccines, 2021
Capsid-like particle (CLP) displays can be used to enhance the immunogenicity of vaccine antigens, but a better understanding of how CLP vaccines are best formulated and delivered is needed.
Christoph M. Janitzek, Philip H. R. Carlsen, Susan Thrane, Vijansh M. Khanna, Virginie Jakob, Christophe Barnier-Quer, Nicolas Collin, Thor G. Theander, Ali Salanti, Morten A. Nielsen, Adam F. Sander   +10 more
doaj   +1 more source

Expression of dengue virus and Zika virus NS2B-NS3pro constructs alter cellular fatty acids, but co-expression with a Zika virus virus-like particle is detrimental to virus-like particle expression

BMC Research Notes, 2023
Objective Studies have shown that Flavivirus infection remodels the host cell to favour viral replication. In particular, the host cell lipid profile is altered, and it has been proposed that this process alters membrane fluidity to allow wrapping of the
Suwipa Ramphan, Nathamon Yimpring, Chontida Tangsongcharoen, Suthatta Sornprasert, Atitaya Hitakarun, Wannapa Sornjai, Sittiruk Roytrakul, Atikorn Panya, Duncan R. Smith   +8 more
doaj   +1 more source

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction. [PDF]

, 2017
LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM).
Agbandje-McKenna, Mavis, Baker, Timothy S, Chipman, Paul, Cotmore, Susan, D'Abramo, Anthony, Geilen, Lorena, Halder, Sujata, Janssen, Mandy, Kurian, Justin, Mckenna, Robert, Misseldine, Adam, Pittman, Nikéa, Smith, J Kennon, Tattersall, Peter   +13 more
core   +3 more sources