Results 71 to 80 of about 187,700 (310)

RNA Phage VLP-Based Vaccine Platforms

open access: yesPharmaceuticals, 2021
Virus-like particles from a variety of RNA bacteriophages have turned out to be useful platforms for delivery of vaccine antigens in a highly immunogenic format.
David S. Peabody   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

White spot syndrome virus envelope protein VP28 is involved in the systemic infection of shrimp [PDF]

open access: yes, 2001
White spot syndrome virus (WSSV) is a large DNA virus infecting shrimp and other crustaceans. The virus particles contain at least five major virion proteins, of which three (VP26, VP24, and VP15) are present in the rod-shaped nucleocapsid and two (VP28 ...
van Hulten, Mariëlle C W   +8 more
core   +1 more source

Particle-like topologies in light [PDF]

open access: yes, 2021
Three-dimensional (3D) topological states resemble truly localised, particle-like objects in physical space. Among the richest such structures are 3D skyrmions and hopfions that realise integer topological numbers in their configuration via homotopic ...
Ramon Droop (10290716)   +7 more
core   +1 more source

Marburg virus-like particles by co-expression of glycoprotein and matrix protein in insect cells induces immune responses in mice

open access: yesVirology Journal, 2017
Background Marburg virus (MARV) causes severe haemorrhagic fever in humans and nonhuman primates and has a high mortality rate. However, effective drugs or licensed vaccines are not currently available to control the outbreak and spread of this disease ...
Weiwei Gai   +16 more
doaj   +1 more source

Virus-like particles as vaccine adjuvants

open access: yesMolecular Biotechnology, 2001
Virus-like particles (VLPs) consist of one or more viral coat proteins that assemble into particles. They can be taken up by antigen presenting cells (APC), peptides derived from them are presented on MHC class I molecules at the cell surface, and thereby prime a CD8+ T cell response, either against the particle-forming protein itself (such as ...
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Virus-Like Particles Assembled Using Respiratory Syncytial Virus Matrix Protein Elicit Protective Immunity in Mice [PDF]

open access: yes, 2023
Su-Hwa Lee,1,* Ki-Back Chu,2,* Min-Ju Kim,3 Fu-Shi Quan1,2 1Department of Medical Zoology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea; 2Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical ...
Chu KB, Quan FS, Lee SH, Kim MJ
core  

Towards an improved platform for dengue and Zika virus virus-like particle production [PDF]

open access: yes, 2022
FAME analysis Using GC-QTOF with HP-88 (100m) column for the manuscript entitled Towards an improved platform for dengue and Zika virus virus-like particle productionTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Panya, A (via Mendeley Data)
core   +1 more source

Virus-Like Particle Vaccination Protects Nonhuman Primates from Lethal Aerosol Exposure with Marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges)

open access: yesViruses, 2016
Marburg virus (MARV) was the first filovirus to be identified following an outbreak of viral hemorrhagic fever disease in Marburg, Germany in 1967. Due to several factors inherent to filoviruses, they are considered a potential bioweapon that could be ...
John M. Dye   +8 more
doaj   +1 more source

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