Results 81 to 90 of about 187,700 (310)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Influenza virus activation of the interferon system [PDF]

, 2015
This study was supported by the Wellcome Trust (grant number 087751/A/08/Z) and the Medical Research Council (grant number G0700848).The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to ...
Fodor, Ervin, Killip, Marian J., Randall, RE, Fodor, E., Killip, MJ, Randall, Richard E., Fodor, E, Killip, M.J., Randall, R.E.   +8 more
core   +2 more sources

Virus-like particles for vaccination against cancer. [PDF]

, 2020
Active immunotherapy of cancer aims to treat the disease by inducing effective cellular and humoral immune responses. Virus-like particle-based vaccines have evolved dramatically over the last few decades, greatly reducing morbidity and mortality of ...
Knuth, Alexander, Alexander Knuth, Knuth, A., Mona O. Mohsen, Bachmann, Martin F., Mohsen, M.O., Speiser, D.E., Mohsen, Mona O., Daniel E. Speiser, Bachmann, M.F., Speiser, Daniel E, Martin F. Bachmann   +11 more
core   +1 more source

Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the immunogenicity of rabies virus-like particles in mice and dogs

Frontiers in Microbiology, 2015
Rabies remains an important worldwide public health threat, so safe, effective and affordable vaccines are still being sought. Virus-like particle (VLP)-based vaccines targeting various viral pathogens have been successfully produced, licensed and ...
Yinglin eQi, Yinglin eQi, Hongtao eKang, Hongtao eKang, Xuexing eZheng, Hualei eWang, Yuwei eGao, Songtao eYang, Xianzhu eXia   +8 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Comparative Molecular Biology Approaches for the Production of Poliovirus Virus-Like Particles Using Pichia pastoris

mSphere, 2020
For enteroviruses such as poliovirus (PV), empty capsids, which are antigenically indistinguishable from mature virions, are produced naturally during viral infection.
Lee Sherry, Keith Grehan, Joseph S. Snowden, Michael L. Knight, Oluwapelumi O. Adeyemi, David J. Rowlands, Nicola J. Stonehouse   +6 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Rapid generation of replication-deficient monovalent and multivalent vaccines for bluetongue virus: protection against virulent virus challenge in cattle and sheep. [PDF]

, 2013
Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have spread throughout Europe, and serotype 8 has suddenly emerged in northern Europe, causing considerable economic losses, direct (mortality and morbidity) but also indirect, due to ...
Hoffmann, B., C.C.P. Celma, Wernike, Kerstin, Eschbaumer, M., Wernike, K., De Clercq, K., van Rijn, Piet A, Haegeman, Andy, Beer, M., B. Hoffmann, A. Haegeman, P.A. van Rijn, van Rijn, P.A., Clercq, K., De, Celma, C.C.P., Eschbaumer, Michael, P. Roy, Boyce, Mark, Roy, Polly, M. Boyce, Roy, P., Hoffmann, Bernd, De Clercq, Kris, Rijn, P.A., van, M. Beer, Boyce, M., M. Eschbaumer, Celma, Cristina CP, K. De Clercq, Beer, Martin, K. Wernike   +30 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses [PDF]

Avian influenza A virus (AIV) is a significant cause of mortality in poultry, causing substantial economic loss, particularly in developing countries, and has zoonotic potential.
Iqbal, Munir, Dunham, Stephen P., Elbohy, Ola A, Janet M. Daly, Stephen P. Dunham, Daly, Janet M., Munir Iqbal, Dunham, Stephen P, Elbohy, Ola A., Daly, Janet M, Ola A. Elbohy   +10 more
core   +2 more sources