Results 41 to 50 of about 457,331 (261)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Nanotherapy and Reactive Oxygen Species (ROS) in Cancer: A Novel Perspective

Antioxidants, 2018
The incidence of numerous types of cancer has been increasing over recent years, representing the second-most frequent cause of death after cardiovascular diseases.
Peter Brenneisen, Andreas S. Reichert
doaj   +1 more source

Endogenous mechanisms of reactive oxygen species (ROS) generation

Postępy Higieny i Medycyny Doświadczalnej, 2016
The main cellular source of reactive oxygen species (ROS) is mitochondrial respiratory chain and active NADPH responsible for "respiratory burst" of phagocytes. Whatsmore ROS are produced in endoplasmic reticulum, peroxisomes, with the participation of xanthine and endothelial oxidase and during autoxidation process of small molecules.
Agata, Sarniak, Joanna, Lipińska, Karol, Tytman, Stanisława, Lipińska   +3 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Reactive oxygen species (ROS) on Ribosome: from damage to regulation

Current Issues in Pharmacy and Medical Sciences
The chemical reactive molecule ROS (Reactive Oxygen Species) is a product of normal cellular metabolism. ROS plays a pivotal role in a wide range of biological processes, including aging, cancer and neurodegenerative diseases.
Emir Behluli, Shefki Xharra, Hilada Nefic, Rifat HadziselimoviC, Gazmend Temaj   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Reactive oxygen species (ROS): sources, generation, disease pathophysiology, and antioxidants

Discover Chemistry
Reactive oxygen species (ROS) are widely known as highly reactive signalling and transcription factors. They have shown beneficial effects at low concentrations to regulate multiple cellular processes like proliferation, differentiation, migration ...
Waseem Ahmad Ansari, Kajal Srivastava, Malik Nasibullah, Mohammad Faheem Khan   +3 more
doaj   +1 more source

Reducing pesticide use: Synthesis and application of ROS-SPC as an efficient nanocarrier and scavenger of reactive oxygen species in plants

Advanced Agrochem
There is an increasing need to reduce the use of pesticides to reduce their potential threat to food/environmental safety. At the same time, an increase in reactive oxygen species (ROS) induced by abiotic stresses in plants can lead to an increase in ROS
Tian-shi Jiang, Su-zhen Qi, Chang-heng Zhu, Han-qing Zhao, Liu-sheng Duan   +4 more
doaj   +1 more source