Results 221 to 230 of about 2,976 (300)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Enhanced power sharing and voltage regulation for islanded nano-satellite DC microgrids in spinning flight scenarios. [PDF]

Sci Rep
Louassaa K, Guerrero JM, Khan B, Yousaf MZ, Zdiri MA, Zhang L, Sivanraju R.   +6 more
europepmc   +1 more source

Physical Origin of Temperature Induced Activation Energy Switching in Electrically Conductive Cement

Advanced Science, EarlyView.
The temperature‐induced Arrhenius activation energy switching phenomenon of electrical conduction in electrically conductive cement originates from structural degradation within the biphasic ionic‐electronic conduction architecture and shows percolation‐governed characteristics: pore network opening dominates the low‐percolation regime with downward ...
Jiacheng Zhang, Xinyuan Ke, Andrew Heath, Richard J. Ball, Jiawei Xie, Jinchen Fan, Guisheng Li, Kevin Paine   +7 more
wiley   +1 more source

High-Throughput Ellipsometric Contrast Microscopy of Lateral 2D Heterostructures for Optoelectronics. [PDF]

Small Methods
Potočnik T, Burton O, Chakraborty SK, Ray P, Mouthaan R, Christopher PJ, Tirandaz Z, Lin X, Joyce HJ, Hofmann S, Sahoo PK, Alexander-Webber JA.   +11 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

A novel wide input range transformerless PV microinverter with natural power decoupling. [PDF]

Sci Rep
Elbaksawi O, Ashour YN, Abouzeid AF, Fawzi M.   +3 more
europepmc   +1 more source

Spatial Engineering of Gas Diffusion Layers Overcomes Mass Transport Limitations in Fuel Cells

Advanced Science, EarlyView.
ABSTRACT Mass transport limitations at high current densities hinder polymer electrolyte fuel cell (PEFC) performance due to inefficient water management and reactant distribution. Gas diffusion layer (GDL) perforation offers a potential solution as an alternative to complex flow‐field modifications.
Shangwei Zhou, Wenjia Du, Jianuo Chen, Yunsong Wu, Bochen Li, Jieyang Li, Linlin Xu, Winfried Kockelmann, Meng Lin, Marc‐Olivier Coppens, Paul R Shearing, Rhodri Jervis, Thomas S. Miller   +12 more
wiley   +1 more source

Optimal sizing and placement of STATCOM, TCSC and UPFC using a novel hybrid genetic algorithm-improved particle swarm optimization. [PDF]

Heliyon
Ngei UM, Nyete AM, Moses PM, Wekesa C.
europepmc   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Comparative analysis of FACT devices for optimal improvement of power quality in unbalanced distribution systems. [PDF]

Sci Rep
Elkholy AM, Panfilov DI, ELGebaly AE.
europepmc   +1 more source