Results 51 to 60 of about 8,573 (198)

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, EarlyView.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Reactive Thrombocytosis in Febrile Infants and Children with Serious Bacterial Infection [PDF]

, 2020
INTRODUCTION: Serious bacterial infection is common in infants and children. Many children with serious bacterial infection at presentation have no identifiable cause other than fever.
Keerthiga, N
core  

Thrombocytosis in patients with spondyloarthritis: a case–control study

BMC Musculoskeletal Disorders, 2023
Objective This study aimed to investigate the clinical and laboratory as well as radiological features of spondyloarthritis (SpA) patients with thrombocytosis and to explore risk factor for thrombocytosis in SpA patients and to assess the effect of ...
Linan Deng, Pingping Zheng
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis

, 2002
International audienceCD40 ligand (CD40L) is expressed on activated CD4(+) T lymphocytes and at the activated platelet surface. A circulating soluble form of CD40L (sCD40L) is generated by the way of a proteolytic cleavage.
Pellegrin, Jean-Luc, Déchanet, Julie, Nurden, Paquita, Nurden, Alan, T., Viallard, Jean-François, Solanilla, Anne, Praloran, Vincent, Contin, Cécile, Ripoche, Jean, Gauthier, Bruno, Grosset, Christophe, F, Moreau, Jean-François   +11 more
core   +1 more source

A case of essential thrombocythemia and ankylosing spondylitis treated with a combination of anagrelide, disease-modifying antirheumatic drugs, and etanercept [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2016
Introduction. A high platelet count, or thrombocytosis, is either a reactive process or a result of a myeloproliferative disorder. Ankylosing spondylitis is a chronic inflammatory rheumatic disease affecting the spine and sometimes peripheral ...
Zeremski Vanja, Savić Aleksandar, Ilić Tatjana, Milošević Ivana, Maksimović Marina, Vučković Biljana   +5 more
doaj   +1 more source

Circulating Thrombopoietin in Clonal Versus Reactive Thrombocytosis

Hematology, 2002
The aim of this study is to assess circulating thrombopoietin concentrations in patients with both clonal and reactive thrombocytosis (RT), which are two distinct categories of extreme platelet production circumstances. Investigation of the thrombopoietin levels in clonal versus reactive thrombocytosis may help us to understand the interactions of this
Sema, Karakuş, Osman I, Ozcebe, Ibrahim C, Haznedaroğlu, Hakan, Göker, Düzgün, Ozatli, Ali, Koşar, Yahya, BüyükaşIk, Derun, Ertuğrul, Nilgün, SayInalp, Serafettin, KirazlI, Semra V, Dündar   +10 more
openaire   +2 more sources

Age‐Associated Variations in Complete Blood Cell Count Parameters and Derived Indices Among Community‐Dwelling Chinese Older Adults

Journal of Clinical Laboratory Analysis, EarlyView.
This cross‐sectional study analyzed data from 9331 participants aged 24–97 to characterize age‐ and sex‐related physiological trajectories of complete blood cell count (CBC) parameters and derived inflammatory indices. Key findings encompassed age‐related declines in red blood cell and platelet counts, elevations in RDW‐CV indices and monocyte ...
Xiangyi Ma, Na Liu, Xiang Wu, Qiudan Chen, Xiaotong Chen, Qingyu Zhou, Shuying Chen, Yong Lin, Xuefeng Wang   +8 more
wiley   +1 more source

Effect of iron therapy on platelet counts in patients with inflammatory bowel disease-associated anemia. [PDF]

PLoS ONE, 2012
Secondary thrombocytosis is a clinical feature of unknown significance. In inflammatory bowel disease (IBD), thrombocytosis is considered a marker of active disease; however, iron deficiency itself may trigger platelet generation. In this study we tested
Stefanie Kulnigg-Dabsch, Rayko Evstatiev, Clemens Dejaco, Christoph Gasche   +3 more
doaj   +1 more source