Results 111 to 120 of about 1,362,026 (232)
The use of Computational Methods for the Assessment of Chemicals in REACH [PDF]
Bioautomation, 2009 This article provides an overview of the use of computational methods in chemicals hazard and risk assessment under the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) legislation. The key aspects of the REACH guidance on the
Tsakovska I., Worth A.
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Bridging science and curriculum: preparing future leaders in computational toxicology
Frontiers in ToxicologyComputational toxicology plays an important role in chemical safety assessments. Computational methods are applied to early-stage screening in drug discovery, hazard identification, and regulatory safety assessment.
Frances Hall, Candice Johnson
doaj +1 more source
Towards systematic read-across using Generalised Read-Across (GenRA). [PDF]
Comput Toxicol, 2023 Patlewicz G, Shah I.
europepmc +1 more source
, 1984 Survival: the key is your desire to live -- O'Dowd speaks out: University needs to become more unified -- Eaglecrest on an uphill glide -- Diet critical for maintaining health -- Watergate: Then and now -- Editorial page -- Bruce Cockburn: The new age ...
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Novel approach for efficient predictions properties of large pool of nanomaterials based on limited set of species: nano-read-across [PDF]
Creating suitable chemical categories and developing read-across methods, supported by quantum mechanical calculations, can be an effective solution to solving key problems related to current scarcity of data on the toxicity of various nanoparticles ...
Cronin, MTD +4 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Next SustainabilityThis study employs a read-across approach, generating similarity-based hypotheses to predict the removal efficiency of VOCs (Volatile Organic Compounds) during the recycling of plastic film waste. The objective was to estimate VOC emissions under various
Md Mobarak Hossain, Kunal Roy
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Testing Strategies for the Prediction of Skin and Eye Irritation and Corrosion for Regulatory Purposes [PDF]
, 2007 This report reviews the use of stepwise testing approaches for the prediction of skin and eye irritation and corrosion in a regulatory context. It is published as a companion report to the "Review of Literature-Based Models for Skin and Eye Irritation ...
GALLEGOS SALINER Ana, WORTH Andrew
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