Results 71 to 80 of about 1,362,026 (232)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
A Compendium of Case Studies that Helped to Shape the REACH Guidance on Chemical Categories and Read Across [PDF]
, 2007 This document pulls together the compendium of case studies that were conducted as part of the REACH project charged with developing technical guidance on the use and formation of chemical grouping approaches (chemical categories/read-across).
TIER GRACE, WORTH ANDREW
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Research to support the development of teacher training and guidance. [PDF]
, 2018 This report in conjunction with a new quality framework for delivering career guidance in schools, will be the foundation of a new web-based resource which will help teachers in schools across Europe to develop their provision in response to these issues.
Hanson, Jill, Moore, Nicki
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Business school techspectations Technology in the daily lives and educational experiences of business students [PDF]
, 2010 Business School Techspectations is the second in a series of reports based on research by the DCU Leadership, Innovation and Knowledge Research Centre (LInK) at DCU Business School.
Alexopoulos, Angelos, Lynn, Theo
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Adverse Outcome Pathway (AOP) Informed Modeling of Aquatic Toxicology: QSARs, Read-Across, and Interspecies Verification of Modes of Action. [PDF]
Alternative approaches have been promoted to reduce the number of vertebrate and invertebrate animals required for the assessment of the potential of compounds to cause harm to the aquatic environment.
Cronin, MTD +4 more
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Looping, Grouping and Aligning the Vowels [PDF]
, 2005 Firstly, a reminder that an AEIOU word is one in which the 5 major vowels occur just once, in any order. The AEIOU words of current concern, however, are limited to those in which the vowels occur in alphabetical circular order or reverse alphabetical ...
Thorpe, Susan
core +1 more source