Results 21 to 30 of about 1,362,093 (292)

Safety of 37 feed additives consisting of flavouring compounds belonging to different chemical groups for use in all animal species (FEFANA asbl)

EFSA Journal, 2022
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the supplementary information submitted on the safety of 37 compounds ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fašmon Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Jaume Galobart, Paola Manini   +19 more
doaj   +1 more source

Integrative Chemical–Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams

Toxics, 2023
Human cell-based test methods can be used to evaluate potential hazards of mixtures and products of petroleum refining (“unknown or variable composition, complex reaction products, or biological materials” substances, UVCBs).
Alexandra C. Cordova, William D. Klaren, Lucie C. Ford, Fabian A. Grimm, Erin S. Baker, Yi-Hui Zhou, Fred A. Wright, Ivan Rusyn   +7 more
doaj   +1 more source

The read-across hypothesis and environmental risk assessment of pharmaceuticals [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. Copyright © 2013 American Chemical Society.Pharmaceuticals in the environment have received increased attention over the past decade, as they are ubiquitous in rivers and ...
Margiotta-Casaluci, L, Owen, SF, Panter, GH, Patel, A, Rand-Weaver, M, Sumpter, JP   +5 more
core   +1 more source

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making [PDF]

, 2014
Background: Safety assessment for repeated dose toxicity is one of the largest challenges in the process to replace animal testing. This is also one of the proof of concept ambitions of SEURAT-1, the largest ever European Union research initiative on ...
Alfonso M. Lostia, Andrew White, Andrew Worth, Catherine Mahony, Derek Knight, Detlef Keller, Edward Carney, Elisabet Berggren, Francoise Gautier, Georges E.N. Kass, Gerrit Schüürmann, Hubert Deluyker, Ivan Rusyn, Julien Burton, Karen Blackburn, Mark Cronin, Michael Schwarz, Patric Amcoff, Richard S. Judson, Romualdo Benigni, Sharon Munn, Terry Schultz, Werner Lilienblum, Wess AJ   +23 more
core   +1 more source

Simulated gastric hydrolysis and developmental toxicity of dimethyltin bis(2-ethylhexylthioglycolate) in rats

Frontiers in Toxicology, 2023
Dimethyltin dichloride is used as the putative toxophore for dimethyltin bis-alkylthio esters in a read-across approach. Recent chemical and toxicological investigations challenges this read across as data on dioctyltin bis(2-ethylhexyl thioglycolate ...
Dominik Kirf, Richard Costlow, Hans Nasshan, Peter Frenkel, Donna Mondimore   +4 more
doaj   +1 more source

Reading Across the World

IASL Annual Conference Proceedings, 2021
21st Century learners live in a shrinking world with advances in technology and transportation with political, social and economic choices made in one corner of the globe affecting the opposite (Friedman, 2005; Zahabioun, Yousefy, Yarmohammadian, & Keshtiaray, 2013).
Kasey L. Garrison, Sue K. Kimmel, Danielle E. Forest   +2 more
openaire   +2 more sources

Nanoparticle surface coatings produce distinct antibacterial effects that are consistent across diverse bacterial species

Frontiers in Toxicology, 2023
Nanoparticles have been proposed as tunable delivery vehicles for targeted treatments and, in some cases, the active therapeutic agents themselves. Despite the promise of such customizable impacts, little evidence exists to support these claims in the ...
Thelma Ameh, Kuzy Zarzosa, Kuzy Zarzosa, W. Evan Braswell, Christie M. Sayes   +4 more
doaj   +1 more source

A generalizable definition of chemical similarity for read-across [PDF]

, 2014
Background: Methods that provide a measure of chemical similarity are strongly relevant in several fields of chemoinformatics as they allow to predict the molecular behavior and fate of structurally close compounds.
Benfenati, Emilio, Floris, Matteo, Manganaro, Alberto, Mangiatordi, Giuseppe Felice, Medda, Ricardo, Nicolotti, Orazio   +5 more
core   +1 more source

CPANNatNIC software for counter-propagation neural network to assist in read-across

Journal of Cheminformatics, 2017
Background CPANNatNIC is software for development of counter-propagation artificial neural network models. Besides the interface for training of a new neural network it also provides an interface for visualisation of the results which was developed to ...
Viktor Drgan, Špela Župerl, Marjan Vračko, Claudia Ileana Cappelli, Marjana Novič   +4 more
doaj   +1 more source

Quantitative cross-species extrapolation between humans and fish: The case of the anti-depressant fluoxetine [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and ...
ABA Boxall, AC Altamura, AC Johnson, Anna de Polo, BJ Ring, C Charlier, C Hiemke, C Lillesaar, C Maximino, CA LaLone, CB Eap, D Baldwin, D Kokel, DB Huggett, DJ Caldwell, DS Baldwin, ED Levin, EJ Perkins, FM McRobb, G Jannuzzi, GG Gould, Grace H. Panter, GT Ankley, J Cachat, J Klooster, J Kristensen, J Lundmark, J Rihel, J Rihel, JA Mennigen, JD Amsterdam, JG Kohlert, Jodi Pawluski, John P. Sumpter, JP Berninger, JP Seiler, JP Sumpter, JP Sumpter, JT Pittman, JV Goldstone, K Kuemmerer, KD Oakes, L Bjerkenstedt, L Fjordside, L Gunnarsson, L Ibrahim, L Margiotta-Casaluci, LD Ellis, Luigi Margiotta-Casaluci, M Rand-Weaver, M Schulz, M Sundvik, M Wolman, MA Lopez-Patino, Mariann Rand-Weaver, Matthew J. Winter, MC Celander, MG Scordo, MJ Airhart, MJ Owens, MJ Winter, MS Lipsky, MW Kelly, PD Anderson, RF Bergstrom, RJ Egan, Rob I. Cumming, RY Wong, SC Baraban, SC Dulawa, SH Preskorn, SH Preskorn, Stewart F. Owen, TJ Runnalls, TR Norman, TW Valenti Jr, TW Valenti Jr, WJAJ Smeets, YH Zhang, YJ Kim, Z Bencan   +80 more
core   +3 more sources