Results 41 to 50 of about 1,362,093 (292)

Read-Across for Rat Oral Gavage Repeated-Dose Toxicity for Short-Chain Mono-Alkylphenols: A Case Study [PDF]

, 2017
Short-chain mono-alkylphenols provide an example of where a category-approach to read-across may be used to estimate the repeated-dose endpoint for a number of derivatives. Specifically, the NOAELs of 50 mg/kg bw/d for mono-methylphenols based on a LOAEL
Bradbury, SP, Cronin, MTD, Mellor, CL, Przybylak, KR, Richarz, AN, Schultz, TW   +5 more
core   +2 more sources

Supporting read-across using biological data [PDF]

ALTEX, 2016
Read-across, i.e. filling toxicological data gaps by relating to similar chemicals, for which test data are available, is usually done based on chemical similarity. Besides structure and physico-chemical properties, however, biological similarity based on biological data adds extra strength to this process. In the context of developing Good Read-Across
Zhu, Hao, Bouhifd, Mounir, Donley, Elizabeth, Egnash, Laura, Kleinstreuer, Nicole, Kroese, E. Dinant, Liu, Zhichao, Luechtefeld, Thomas, Palmer, Jessica, Pamies, David, Shen, Jie, Strauss, Volker, Wu, Shengde, Hartung, Thomas   +13 more
openaire   +4 more sources

Interpretation of murine local lymph node assay (LLNA) data for skin sensitization: Overload effects, danger signals and chemistry-based read-across

Current Research in Toxicology, 2021
There is a large body of information on testing of chemicals for skin sensitization in the murine local lymph node assay (LLNA), in which potency is quantified by the EC3 value, derived from dose-response data.
David W. Roberts
doaj   +1 more source

lazar: A modular predictive toxicology framework

Frontiers in Pharmacology, 2013
lazar (lazy structure-activity relationships) is a modular framework for predictive toxicology. Similar to the read across procedure in toxicological risk assessment, lazar creates local QSAR models for each compound to be predicted. Model developers can
Andreas eMaunz, Martin eGütlein, Micha eRautenberg, David eVorgrimmler, Denis eGebele, Christoph eHelma   +5 more
doaj   +1 more source

KnowTox: pipeline and case study for confident prediction of potential toxic effects of compounds in early phases of development

Journal of Cheminformatics, 2020
Risk assessment of newly synthesised chemicals is a prerequisite for regulatory approval. In this context, in silico methods have great potential to reduce time, cost, and ultimately animal testing as they make use of the ever-growing amount of available
Andrea Morger, Miriam Mathea, Janosch H. Achenbach, Antje Wolf, Roland Buesen, Klaus-Juergen Schleifer, Robert Landsiedel, Andrea Volkamer   +7 more
doaj   +1 more source

Grouping of nanomaterials to read-across hazard endpoints: from data collection to assessment of the grouping hypothesis by application of chemoinformatic techniques

Particle and Fibre Toxicology, 2018
Background An increasing number of manufactured nanomaterials (NMs) are being used in industrial products and need to be registered under the REACH legislation.
L. Lamon, D. Asturiol, A. Richarz, E. Joossens, R. Graepel, K. Aschberger, A. Worth   +6 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Physiologically based kinetic (PBK) modeling of propiconazole using a machine learning-enhanced read-across approach for interspecies extrapolation

Environment International
A significant challenge in the traditional human health risk assessment of agrochemicals is the uncertainty in quantifying the interspecies differences between animal models and humans.
Yaoxing Wu, Gabriel Sinclair, Raghavendhran Avanasi, Alison Pecquet   +3 more
doaj   +1 more source

Short-read and long-read full-length transcriptome of mouse neural stem cells across neurodevelopmental stages

Scientific Data, 2022
Measurement(s) transcriptomic datasets of neural stem cells Technology Type(s) Next-Generation Sequencing(NGS) • third-generation full-length sequencing(TGS) Sample Characteristic - Organism Mus musculus Sample Characteristic - Environment laboratory ...
Chaoqiong Ding, Xiang Yan, Mengying Xu, Ran Zhou, Yuancun Zhao, Dan Zhang, Zongyao Huang, Zhenzhong Pan, Peng Xiao, Huifang Li, Lu Chen, Yuan Wang   +11 more
doaj   +1 more source

Affective continuities across Muslim and Christian settings in Berlin [PDF]

, 2020
This article, a reflection on collaborative fieldwork involving a Sufi Muslim and a Pentecostal Christian setting in Berlin, examines whether distinct and diverse religious groups can be brought into a meaningful relation with one another.
Kasmani, Omar, Mattes, Dominik
core   +1 more source