Scientific Opinion on Evaluation of the Toxicological Relevance of Pesticide Metabolites for Dietary Risk Assessment [PDF]
EFSA Journal, 2012 <p>The European Food Safety Authority (EFSA) asked the Panel on Plant Protection Products and their Residues (PPR) to develop an opinion on approaches to evaluate the toxicological relevance of metabolites and degradates of pesticide active ...
EFSA Panel on Plant Protection Products and their Residues
doaj +1 more source
Neuroactive drugs and other pharmaceuticals found in blood plasma of wild European fish
Environment International, 2021 To gain a better understanding of which pharmaceuticals could pose a risk to fish, 94 pharmaceuticals representing 23 classes were analyzed in blood plasma from wild bream, chub, and roach captured at 18 sites in Germany, the Czech Republic and the UK ...
Daniel Cerveny +9 more
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Addressing a bottle neck for regulation of nanomaterials: quantitative read-across (Nano-QRA) algorithm for cases when only limited data is available [PDF]
, 2017 The number and variety of engineered nanoparticles have been growing exponentially. Since the experimental evaluation of nanoparticles causing public health concerns is expensive and time consuming, efficient computational tools are amongst the most ...
Arts +43 more
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Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment
Nanomaterials, 2020 Transcriptomics data are relevant to address a number of challenges in Toxicogenomics (TGx). After careful planning of exposure conditions and data preprocessing, the TGx data can be used in predictive toxicology, where more advanced modelling techniques
Angela Serra +19 more
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Read-across of 90-Day Rat Oral Repeated-Dose Toxicity: A Case Study for Selected 2-Alkyl-1-alkanols [PDF]
, 2017 2-Alkyl-1-alkanols offer an example whereby the category approach to read-across can be used to predict repeated-dose toxicity for a variety of derivatives.
Bradbury, S.P +5 more
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Frontiers in Pharmacology, 2018 This study compares the accuracy of (Q)SAR/read-across predictions with the experimental variability of chronic lowest-observed-adverse-effect levels (LOAELs) from in vivo experiments.
Christoph Helma +7 more
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Predictive framework for estimating exposure of birds to pharmaceuticals [PDF]
, 2017 Here we present and evaluate a framework for estimating concentrations of pharmaceuticals over time in wildlife feeding at wastewater treatment plants (WWTPs).
Almroth +72 more
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Counter-stereotypical pictures as a strategy for overcoming spontaneous gender stereotypes [PDF]
, 2015 The present research investigated the use of counter-stereotypical pictures as a strategy for overcoming spontaneous gender stereotypes when certain social role nouns and professional terms are read.
Bar-Anan +54 more
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Read-Across of 90-day Rat Oral Repeated-Dose Toxicity: A Case Study for Selected n-Alkanols [PDF]
, 2017 n-Alkanols provide an excellent example where a category-approach to read-across may be used to estimate the repeated-dose endpoint for a number of untested derivatives (target chemicals) using experimental data for tested derivatives (source chemicals).
Alifimoff +35 more
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Frontiers in Pharmacology, 2017 The lazar framework for read across predictions was expanded for the prediction of nanoparticle toxicities, and a new methodology for calculating nanoparticle descriptors from core and coating structures was implemented.
Christoph Helma +2 more
doaj +1 more source