Results 1 to 10 of about 1,362,026 (232)

Virtual Extensive Read-Across: A New Open-Access Software for Chemical Read-Across and Its Application to the Carcinogenicity Assessment of Botanicals [PDF]

Molecules, 2022
Read-across applies the principle of similarity to identify the most similar substances to represent a given target substance in data-poor situations. However, differences between the target and the source substances exist.
Edoardo Luca Viganò, Erika Colombo, Giuseppa Raitano, Alberto Manganaro, Alessio Sommovigo, Jean Lou CM Dorne, Emilio Benfenati   +6 more
doaj   +2 more sources

“intelligent Read Across (iRA)”- A tool for read-across-based toxicity prediction of nanoparticles [PDF]

Computational and Structural Biotechnology Journal
The rapid advancement of nanotechnology has enabled the use of nanoparticles (NPs) in various applications, such as medicine, electrochemical sensors, and cosmetics, due to their unique physical and chemical properties.
Souvik Pore, Kunal Roy
doaj   +2 more sources

A KNIME Workflow to Assist the Analogue Identification for Read-Across, Applied to Aromatase Activity [PDF]

Molecules, 2023
The reduction and replacement of in vivo tests have become crucial in terms of resources and animal benefits. The read-across approach reduces the number of substances to be tested, exploiting existing experimental data to predict the properties of ...
Ana Yisel Caballero Alfonso, Chayawan Chayawan, Domenico Gadaleta, Alessandra Roncaglioni, Emilio Benfenati   +4 more
doaj   +2 more sources

Computational Modeling of Human Serum Albumin Binding of Per- and Polyfluoroalkyl Substances Employing QSAR, Read-Across, and Docking [PDF]

Molecules, 2023
Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals in widespread use that have been shown to be toxic to wildlife and humans.
Andrea Gallagher, Supratik Kar, Maria S. Sepúlveda   +2 more
doaj   +2 more sources

Article title: Transcriptional profiling efficacy to define biological activity similarity for cosmetic ingredients’ safety assessment based on next-generation read-across [PDF]

Frontiers in Toxicology, 2022
The objective of this work was to use transcriptional profiling to assess the biological activity of structurally related chemicals to define their biological similarity and with that, substantiate the validity of a read-across approach usable in risk ...
Jorge M. Naciff, Yuquing K. Shan, Xiaohong Wang, George P. Daston   +3 more
doaj   +2 more sources

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA’s RAAF, and good read-across practice [PDF]

Frontiers in Toxicology
Read-across has matured from an expert-driven extrapolation based largely on structural analogy into a rigorously documented, mechanistically informed cornerstone of next-generation risk assessment.
Thomas Hartung, Thomas Hartung, Thomas Hartung, Thomas Hartung, Costanza Rovida, Costanza Rovida   +5 more
doaj   +2 more sources

Guidance on the use of read‐across for chemical safety assessment in food and feed [PDF]

EFSA Journal
Read‐across is a method used in chemical risk assessment to predict the toxicological properties of a target substance by using data from structurally and mechanistically similar substances, known as source substances.
EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Pikka Jokelainen, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Edoardo Villa, Holger Zorn, Emilio Benfenati, Romualdo Benigni, Qasim Chaudhry, Lucian Farcal, George Kass, Alexis Nathanail, Alicia Paini, Rositsa Serafimova   +26 more
doaj   +2 more sources

Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones [PDF]

Frontiers in Toxicology, 2023
This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones.
Christina Drake, Matthias M. Wehr, Walter Zobl, Jeannette Koschmann, David De Lucca, Britta A. Kühne, Tanja Hansen, Jan Knebel, Detlef Ritter, Jan Boei, Harry Vrieling, Annette Bitsch, Sylvia E. Escher   +12 more
doaj   +2 more sources

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion [PDF]

Frontiers in Pharmacology
Introduction: We performed an exposure-based Next Generation Risk Assessment case read-across study using New Approach Methodologies (NAMs) to determine the highest safe concentration of daidzein in a body lotion, based on its similarities with its ...
Abdulkarim Najjar, Jochen Kühnl, Daniela Lange, Camille Géniès, Carine Jacques, Eric Fabian, Anne Zifle, Nicola J. Hewitt, Andreas Schepky   +8 more
doaj   +2 more sources

RAID: Regression Analysis–Based Inductive DNA Microarray for Precise Read-Across [PDF]

Frontiers in Pharmacology, 2022
Chemical structure-based read-across represents a promising method for chemical toxicity evaluation without the need for animal testing; however, a chemical structure is not necessarily related to toxicity. Therefore, in vitro studies were often used for
Yuto Amano, Masayuki Yamane, Hiroshi Honda   +2 more
doaj   +2 more sources