Results 41 to 50 of about 1,362,026 (232)

Nano-Lazar: Read across Predictions for Nanoparticle Toxicities with Calculated and Measured Properties

Frontiers in Pharmacology, 2017
The lazar framework for read across predictions was expanded for the prediction of nanoparticle toxicities, and a new methodology for calculating nanoparticle descriptors from core and coating structures was implemented.
Christoph Helma, Micha Rautenberg, Denis Gebele   +2 more
doaj   +1 more source

KnowTox: pipeline and case study for confident prediction of potential toxic effects of compounds in early phases of development

Journal of Cheminformatics, 2020
Risk assessment of newly synthesised chemicals is a prerequisite for regulatory approval. In this context, in silico methods have great potential to reduce time, cost, and ultimately animal testing as they make use of the ever-growing amount of available
Andrea Morger, Miriam Mathea, Janosch H. Achenbach, Antje Wolf, Roland Buesen, Klaus-Juergen Schleifer, Robert Landsiedel, Andrea Volkamer   +7 more
doaj   +1 more source

Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment

Nanomaterials, 2020
Transcriptomics data are relevant to address a number of challenges in Toxicogenomics (TGx). After careful planning of exposure conditions and data preprocessing, the TGx data can be used in predictive toxicology, where more advanced modelling techniques
Angela Serra, Michele Fratello, Luca Cattelani, Irene Liampa, Georgia Melagraki, Pekka Kohonen, Penny Nymark, Antonio Federico, Pia Anneli Sofia Kinaret, Karolina Jagiello, My Kieu Ha, Jang-Sik Choi, Natasha Sanabria, Mary Gulumian, Tomasz Puzyn, Tae-Hyun Yoon, Haralambos Sarimveis, Roland Grafström, Antreas Afantitis, Dario Greco   +19 more
doaj   +1 more source

Short-read and long-read full-length transcriptome of mouse neural stem cells across neurodevelopmental stages

Scientific Data, 2022
Measurement(s) transcriptomic datasets of neural stem cells Technology Type(s) Next-Generation Sequencing(NGS) • third-generation full-length sequencing(TGS) Sample Characteristic - Organism Mus musculus Sample Characteristic - Environment laboratory ...
Chaoqiong Ding, Xiang Yan, Mengying Xu, Ran Zhou, Yuancun Zhao, Dan Zhang, Zongyao Huang, Zhenzhong Pan, Peng Xiao, Huifang Li, Lu Chen, Yuan Wang   +11 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

lazar: A modular predictive toxicology framework

Frontiers in Pharmacology, 2013
lazar (lazy structure-activity relationships) is a modular framework for predictive toxicology. Similar to the read across procedure in toxicological risk assessment, lazar creates local QSAR models for each compound to be predicted. Model developers can
Andreas eMaunz, Martin eGütlein, Micha eRautenberg, David eVorgrimmler, Denis eGebele, Christoph eHelma   +5 more
doaj   +1 more source

Simulated gastric hydrolysis and developmental toxicity of dimethyltin bis(2-ethylhexylthioglycolate) in rats

Frontiers in Toxicology, 2023
Dimethyltin dichloride is used as the putative toxophore for dimethyltin bis-alkylthio esters in a read-across approach. Recent chemical and toxicological investigations challenges this read across as data on dioctyltin bis(2-ethylhexyl thioglycolate ...
Dominik Kirf, Richard Costlow, Hans Nasshan, Peter Frenkel, Donna Mondimore   +4 more
doaj   +1 more source

Affective continuities across Muslim and Christian settings in Berlin [PDF]

, 2020
This article, a reflection on collaborative fieldwork involving a Sufi Muslim and a Pentecostal Christian setting in Berlin, examines whether distinct and diverse religious groups can be brought into a meaningful relation with one another.
Kasmani, Omar, Mattes, Dominik
core   +1 more source

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source

Physiologically based kinetic (PBK) modeling of propiconazole using a machine learning-enhanced read-across approach for interspecies extrapolation

Environment International
A significant challenge in the traditional human health risk assessment of agrochemicals is the uncertainty in quantifying the interspecies differences between animal models and humans.
Yaoxing Wu, Gabriel Sinclair, Raghavendhran Avanasi, Alison Pecquet   +3 more
doaj   +1 more source