Results 21 to 30 of about 1,362,026 (232)

The read-across hypothesis and environmental risk assessment of pharmaceuticals [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. Copyright © 2013 American Chemical Society.Pharmaceuticals in the environment have received increased attention over the past decade, as they are ubiquitous in rivers and ...
Margiotta-Casaluci, L, Owen, SF, Panter, GH, Patel, A, Rand-Weaver, M, Sumpter, JP   +5 more
core   +1 more source

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making [PDF]

, 2014
Background: Safety assessment for repeated dose toxicity is one of the largest challenges in the process to replace animal testing. This is also one of the proof of concept ambitions of SEURAT-1, the largest ever European Union research initiative on ...
Alfonso M. Lostia, Andrew White, Andrew Worth, Catherine Mahony, Derek Knight, Detlef Keller, Edward Carney, Elisabet Berggren, Francoise Gautier, Georges E.N. Kass, Gerrit Schüürmann, Hubert Deluyker, Ivan Rusyn, Julien Burton, Karen Blackburn, Mark Cronin, Michael Schwarz, Patric Amcoff, Richard S. Judson, Romualdo Benigni, Sharon Munn, Terry Schultz, Werner Lilienblum, Wess AJ   +23 more
core   +1 more source

Integrative Chemical–Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams

Toxics, 2023
Human cell-based test methods can be used to evaluate potential hazards of mixtures and products of petroleum refining (“unknown or variable composition, complex reaction products, or biological materials” substances, UVCBs).
Alexandra C. Cordova, William D. Klaren, Lucie C. Ford, Fabian A. Grimm, Erin S. Baker, Yi-Hui Zhou, Fred A. Wright, Ivan Rusyn   +7 more
doaj   +1 more source

Toward Good Read-Across Practice (GRAP) guidance. [PDF]

, 2016
Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments.
Ball, N, Blackburn, K, Booth, ED, Bouhifd, M, Cronin, MTD, Donley, E, Egnash, L, Hartung, T, Hastings, C, Juberg, DR, Kleensang, A, Kleinstreuer, N, Kroese, ED, Lee, AC, Luechtefeld, T, Maertens, A, Marty, S, Naciff, JM, Palmer, J, Pamies, D, Patlewicz, G, Penman, M, Richarz, AN, Russo, DP, Shen, J, Stuard, SB, van Ravenzwaay, B, Wu, S, Zhu, H   +28 more
core   +2 more sources

Nanoparticle surface coatings produce distinct antibacterial effects that are consistent across diverse bacterial species

Frontiers in Toxicology, 2023
Nanoparticles have been proposed as tunable delivery vehicles for targeted treatments and, in some cases, the active therapeutic agents themselves. Despite the promise of such customizable impacts, little evidence exists to support these claims in the ...
Thelma Ameh, Kuzy Zarzosa, Kuzy Zarzosa, W. Evan Braswell, Christie M. Sayes   +4 more
doaj   +1 more source

A generalizable definition of chemical similarity for read-across [PDF]

, 2014
Background: Methods that provide a measure of chemical similarity are strongly relevant in several fields of chemoinformatics as they allow to predict the molecular behavior and fate of structurally close compounds.
Benfenati, Emilio, Floris, Matteo, Manganaro, Alberto, Mangiatordi, Giuseppe Felice, Medda, Ricardo, Nicolotti, Orazio   +5 more
core   +1 more source

Neuroactive drugs and other pharmaceuticals found in blood plasma of wild European fish

Environment International, 2021
To gain a better understanding of which pharmaceuticals could pose a risk to fish, 94 pharmaceuticals representing 23 classes were analyzed in blood plasma from wild bream, chub, and roach captured at 18 sites in Germany, the Czech Republic and the UK ...
Daniel Cerveny, Roman Grabic, Kateřina Grabicová, Tomáš Randák, D.G. Joakim Larsson, Andrew C. Johnson, Monika D. Jürgens, Mats Tysklind, Richard H. Lindberg, Jerker Fick   +9 more
doaj   +1 more source

Quantitative cross-species extrapolation between humans and fish: The case of the anti-depressant fluoxetine [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and ...
ABA Boxall, AC Altamura, AC Johnson, Anna de Polo, BJ Ring, C Charlier, C Hiemke, C Lillesaar, C Maximino, CA LaLone, CB Eap, D Baldwin, D Kokel, DB Huggett, DJ Caldwell, DS Baldwin, ED Levin, EJ Perkins, FM McRobb, G Jannuzzi, GG Gould, Grace H. Panter, GT Ankley, J Cachat, J Klooster, J Kristensen, J Lundmark, J Rihel, J Rihel, JA Mennigen, JD Amsterdam, JG Kohlert, Jodi Pawluski, John P. Sumpter, JP Berninger, JP Seiler, JP Sumpter, JP Sumpter, JT Pittman, JV Goldstone, K Kuemmerer, KD Oakes, L Bjerkenstedt, L Fjordside, L Gunnarsson, L Ibrahim, L Margiotta-Casaluci, LD Ellis, Luigi Margiotta-Casaluci, M Rand-Weaver, M Schulz, M Sundvik, M Wolman, MA Lopez-Patino, Mariann Rand-Weaver, Matthew J. Winter, MC Celander, MG Scordo, MJ Airhart, MJ Owens, MJ Winter, MS Lipsky, MW Kelly, PD Anderson, RF Bergstrom, RJ Egan, Rob I. Cumming, RY Wong, SC Baraban, SC Dulawa, SH Preskorn, SH Preskorn, Stewart F. Owen, TJ Runnalls, TR Norman, TW Valenti Jr, TW Valenti Jr, WJAJ Smeets, YH Zhang, YJ Kim, Z Bencan   +80 more
core   +3 more sources

CPANNatNIC software for counter-propagation neural network to assist in read-across

Journal of Cheminformatics, 2017
Background CPANNatNIC is software for development of counter-propagation artificial neural network models. Besides the interface for training of a new neural network it also provides an interface for visualisation of the results which was developed to ...
Viktor Drgan, Špela Župerl, Marjan Vračko, Claudia Ileana Cappelli, Marjana Novič   +4 more
doaj   +1 more source

Addressing a bottle neck for regulation of nanomaterials: quantitative read-across (Nano-QRA) algorithm for cases when only limited data is available [PDF]

, 2017
The number and variety of engineered nanoparticles have been growing exponentially. Since the experimental evaluation of nanoparticles causing public health concerns is expensive and time consuming, efficient computational tools are amongst the most ...
Arts, Arts, Asuero, Ball, Benfenati, Blackburn, Cattaneo, Epa, Fourches, Fourches, Gajewicz, Gajewicz, Gajewicz, Gebel, Godwin, Gottardo, Hansen, Kar, Kar, Liu, Lubinski, Lynch, Morris, Müller, Nel, Nel, OECD, OECD, Oomen, Pan, Pathakoti, Patlewicz, Puzyn, Puzyn, Schultz, Singh, Sizochenko, Stone, Toropov, Winkler, Xia, Xiao, Zhang, Zheng   +43 more
core   +1 more source