Results 11 to 20 of about 1,362,026 (232)

Development of hybrid models by the integration of the read-across hypothesis with the QSAR framework for the assessment of developmental and reproductive toxicity (DART) tested according to OECD TG 414 [PDF]

Toxicology Reports
The governing laws mandate animal testing guidelines (TG) to assess the developmental and reproductive toxicity (DART) potential of new and current chemical compounds for the categorization, hazard identification, and labeling.
Sapna Kumari Pandey, Kunal Roy
doaj   +2 more sources

Identifying chemicals based on receptor binding/bioactivation/mechanistic explanation associated with potential to elicit hepatotoxicity and to support structure activity relationship-based read-across [PDF]

Current Research in Toxicology, 2023
The liver is the most common target organ in toxicology studies. The development of chemical structural alerts for identifying hepatotoxicity will play an important role in in silico model prediction and help strengthen the identification of analogs used
Shengde Wu, George Daston, Jane Rose, Karen Blackburn, Joan Fisher, Allison Reis, Bastian Selman, Jorge Naciff   +7 more
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OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data [PDF]

Frontiers in Pharmacology
The development of new approach methodologies (NAMs) for next-generation risk assessment (NGRA) requires the integration of diverse data streams. A comprehensive understanding of a chemical’s potential hazard involves combining multiple mechanistic data,
Austin Ross, Vijay Gombar, Alexander Sedykh, Adrian J. Green, Alexandre Borrel, Brian Kidd, Jason Phillips, Mihir Shah, Dhiral Phadke, Deepak Mav, Michelle Balik-Meisner, Brian Howard, Ruchir Shah, Nicole C Kleinstreuer, Warren Michael Casey   +14 more
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Contribution of statistical learning in learning to read across languages. [PDF]

PLoS ONE
Statistical Learning (SL) refers to human's ability to detect regularities from environment Kirkham, N. Z. (2002) & Saffran, J. R. (1996). There has been a growing interest in understanding how sensitivity to statistical regularities influences learning ...
Jinglei Ren, Min Wang
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In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR [PDF]

Frontiers in Pharmacology, 2019
A plethora of databases exist online that can assist in in silico chemical or drug safety assessment. However, a systematic review and grouping of databases, based on purpose and information content, consolidated in a single source, has been lacking.
Gopal Pawar, Judith C. Madden, David Ebbrell, James W. Firman, Mark T. D. Cronin   +4 more
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Are synthetic glucocorticoids in the aquatic environment a risk to fish?

Environment International, 2022
The glucocorticosteroid, or glucocorticoid (GC), system is largely conserved across vertebrates and plays a central role in numerous vital physiological processes including bone development, immunomodulation, and modification of glucose metabolism and ...
Charles M. Hamilton, Matthew J. Winter, Luigi Margiotta-Casaluci, Stewart F. Owen, Charles R. Tyler   +4 more
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Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study

Particle and Fibre Toxicology, 2022
Background The EU-project GRACIOUS developed an Integrated Approach to Testing and Assessment (IATA) to support grouping high aspect ratio nanomaterials (HARNs) presenting a similar inhalation hazard.
Fiona Murphy, Nicklas Raun Jacobsen, Emilio Di Ianni, Helinor Johnston, Hedwig Braakhuis, Willie Peijnenburg, Agnes Oomen, Teresa Fernandes, Vicki Stone   +8 more
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Safety of 41 flavouring compounds providing a herbal flavour and belonging to different chemical groups for use as feed additives in all animal species (FEFANA asbl)

EFSA Journal, 2023
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety of 41 compounds to provide a Herbal flavour and belonging to different chemical groups, when used as sensory additives in feed for all animal ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Noël Dierick, Giovanna Martelli, Johannes Westendorf, Jordi Ortuño Casanova, Yvette Dirven, Joana P Firmino, Paola Manini   +25 more
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Safety of 27 flavouring compounds providing a milky‐vanilla flavour and belonging to different chemical groups for use as feed additives in all animal species (FEFANA asbl)

EFSA Journal, 2023
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety of 27 compounds to provide a milky‐vanilla flavour belonging to different chemical groups, when used as sensory additives in feed for all ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fašmon Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Noël Dierick, Giovanna Martelli, Johannes Westendorf, Montserrat Anguita, Jordi Ortuño Casanova, Paola Manini   +25 more
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Safety of 37 feed additives consisting of flavouring compounds belonging to different chemical groups for use in all animal species (FEFANA asbl)

EFSA Journal, 2022
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the supplementary information submitted on the safety of 37 compounds ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fašmon Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Jaume Galobart, Paola Manini   +19 more
doaj   +1 more source