Results 31 to 40 of about 1,362,026 (232)

Read-across of 90-Day Rat Oral Repeated-Dose Toxicity: A Case Study for Selected 2-Alkyl-1-alkanols [PDF]

, 2017
2-Alkyl-1-alkanols offer an example whereby the category approach to read-across can be used to predict repeated-dose toxicity for a variety of derivatives.
Bradbury, S.P, Cronin, M.T.D, Mellor, Claire, Przybylak, P.R, Richardz, A-N, Schultz, T.W   +5 more
core   +3 more sources

Guidance on the establishment of the residue definition for dietary risk assessment

EFSA Journal, 2016
EFSA has asked the Panel on Plant Protection Products and their Residues to prepare guidance on the establishment of the residue definition for dietary risk assessment.
EFSA Panel on Plant Protection Products and their Residues (PPR)
doaj   +1 more source

Predictive framework for estimating exposure of birds to pharmaceuticals [PDF]

, 2017
Here we present and evaluate a framework for estimating concentrations of pharmaceuticals over time in wildlife feeding at wastewater treatment plants (WWTPs).
Almroth, Arnold, Arnold, Bardal, Bean, Bean, Bean, Bolo, Bossus, Boxall, Boxall, Brooks, Brooks, Brooks, Brown, Caccia, Carter, Cummings, Di Poi, East, Fadee, Farner, Feare, Fuller, Goessens, Guler, Gunnarson, Guo, Hiemke, Holladay, Hutchinson, Jjemba, Kasprzyk-Hordern, Kimura, Kostich, Lazarus, Lefebvre, Lesch, Levey, Lienert, Loos, Lopez-Lopez, Margiotta-Casaluci, Markman, Markman, Martinez-Haro, Metcalfe, Meteyer, Monteiro, Monteiro, Naidoo, Ort, Owen, Owen, Pompanon, Rand-Weaver, Rattner, Roberts, Romjin, Ruby, Seehusen, Sharma, Shoulson, Silva, Sperry, Sperry, Tong, Unceta, Vartazarmian, Weinberger, White, Williams, Ziswler   +72 more
core   +1 more source

Counter-stereotypical pictures as a strategy for overcoming spontaneous gender stereotypes [PDF]

, 2015
The present research investigated the use of counter-stereotypical pictures as a strategy for overcoming spontaneous gender stereotypes when certain social role nouns and professional terms are read.
Bar-Anan, Bargh, Blair, Blair, Blascovich, Bodenhausen, Bodenhausen, Carreiras, Coats, Cohen, Dasgupta, Dasgupta, Devine, Diekman, Dijksterhuis, Duffy, Dunlap, Finnegan, Frick, Gabriel, Garnham, Garnham, Gawronski, Girden, Gottfredson, Gottfredson, Green, Greenwald, Hamilton, Hellinger, Irmen, Irmen, Joy-Gaba, Kawakami, Kennison, Kreiner, Kunda, Lai, Lai, Lakens, Lassonde, Lenton, Liben, Macrae, Merry, Moser, Oakhill, Operario, Paluck, Pettigrew, Puhl, Reynolds, Schneider, Shiffrin, Stangor   +54 more
core   +2 more sources

Read-Across of 90-day Rat Oral Repeated-Dose Toxicity: A Case Study for Selected n-Alkanols [PDF]

, 2017
n-Alkanols provide an excellent example where a category-approach to read-across may be used to estimate the repeated-dose endpoint for a number of untested derivatives (target chemicals) using experimental data for tested derivatives (source chemicals).
Alifimoff, Benane, Berggren, Bingham, Butterworth, Edelfors, Fang, He, ITII (International Technical Information Institute), Judson, Kamil, Koleva, McCreery, McKarns, McKim, Mellor, Moyes, Opdyke, Patocka, Pringle, Przybylak, Raevsky, Richard, Schultz, Schultz, Schultz, Strubelt, Teubner, Truhaut, US EPA ToxCast, Veith, Veith, Verschueren, Voet, Voskoboinikova, Williams   +35 more
core   +1 more source

Read-Across for Rat Oral Gavage Repeated-Dose Toxicity for Short-Chain Mono-Alkylphenols: A Case Study [PDF]

, 2017
Short-chain mono-alkylphenols provide an example of where a category-approach to read-across may be used to estimate the repeated-dose endpoint for a number of derivatives. Specifically, the NOAELs of 50 mg/kg bw/d for mono-methylphenols based on a LOAEL
Bradbury, SP, Cronin, MTD, Mellor, CL, Przybylak, KR, Richarz, AN, Schultz, TW   +5 more
core   +2 more sources

Moving towards a holistic approach for human health risk assessment – Is the current approach fit for purpose?

EFSA Journal, 2019
It is recognised that new scientific improvements and their integration in risk assessment, as outlined in the National Academies of Sciences, Engineering and Medicine 2017 report, have the potential to improve human health risk assessments by enabling a
Susanne Hougaard Bennekou
doaj   +1 more source

Modeling Chronic Toxicity: A Comparison of Experimental Variability With (Q)SAR/Read-Across Predictions

Frontiers in Pharmacology, 2018
This study compares the accuracy of (Q)SAR/read-across predictions with the experimental variability of chronic lowest-observed-adverse-effect levels (LOAELs) from in vivo experiments.
Christoph Helma, David Vorgrimmler, Denis Gebele, Martin Gütlein, Barbara Engeli, Jürg Zarn, Benoit Schilter, Elena Lo Piparo   +7 more
doaj   +1 more source

Interpretation of murine local lymph node assay (LLNA) data for skin sensitization: Overload effects, danger signals and chemistry-based read-across

Current Research in Toxicology, 2021
There is a large body of information on testing of chemicals for skin sensitization in the murine local lymph node assay (LLNA), in which potency is quantified by the EC3 value, derived from dose-response data.
David W. Roberts
doaj   +1 more source

Predicting toxicity of chemicals: software beats animal testing

EFSA Journal, 2019
We created earlier a large machine‐readable database of 10,000 chemicals and 800,000 associated studies by natural language processing of the public parts of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registrations until
Thomas Hartung
doaj   +1 more source