Results 81 to 90 of about 3,474,148 (258)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

LA TRADUCCIÓN Y LOS GÉNEROS PERIODÍSTICOS

open access: yesMutatis Mutandis, 2014
Resumen: El papel que juega la traducción en el mundo del periodismo es esencial. A menudo leemos noticias, artículos, columnas y todo tipo de documentos periodísticos en nuestros diarios sin ser conscientes de que estamos, en la mayoría de los casos ...
Alessandro Ghignoli   +1 more
doaj  

Pues no se pudo... del todo

open access: yesCPU-e, 2013
En este texto se exponen el desarrollo y las experiencias obtenidas durante la implementación de un proyecto denominado Sí se puede, Teocelo: promoción cultural y construcción local de ciudadanías, de dos años de duración.
Dr. Jorge Vaca Uribe   +1 more
doaj   +1 more source

A comparison of recall using factual study guides versus elaborative thinking study guides in grade four [PDF]

open access: yes, 1959
Thesis (Ed.M.)--Boston University N.B.: Missing pgs ...
Daniels, Nancy   +3 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

A survey thesis of the personal reading preferences of children in the intermediate grades [PDF]

open access: yes, 1962
Thesis (Ed.M.)--Boston ...
Berkowitz, H. Philip   +3 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

EL QUIJOTE: DIALOGISMO Y VEROSIMILITUD

open access: yesRevista Chilena de Literatura, 2005
El presente ensayo demuestra cómo El Quijote cumple a la perfección con los requisitos del modelo novelístico que Mijail Bajtin consideraba más evolucionado, clásico y puro: el que realiza todas las posibilidades literarias de la palabra novelesca ...
Darío Villanueva
doaj  

A workbook of exercises for following directions to be used with high achieving children in grades one, three and five [PDF]

open access: yes, 1963
Thesis (Ed.M.)--Boston ...
Concannon, Anne S.   +3 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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