Results 61 to 70 of about 684,020 (217)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Hacia Una Poética “Provinciana” Del Recuerdo: Estar Aquí/Ser Allá En La Obra Literaria De Exilio De Osvaldo Rodríguez Musso. Going Forwards To A “Provincial” Poetics Of Remenbrance: To Be Here/ To Be There In The Exile Literary Work Of Osvaldo Rodríguez

Logos: Revista de Lingüística, Literatura y Filosofía, 2011
RESUMEN A la luz de la categoría espacio ontológica Estar aquí/ser allá, que postulamos como herramienta de análisis, leeremos algunos textos significativos dentro de la obra literaria (se hace la distinción debido a que también incursionó en el dibujo y,
Hugo Herrera Pardo
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

UNA HERRAMIENTA DE DIAGNÓSTICO PARA ENLACES DE SUSCRIPCIÓN DIGITAL ASIMÉTRICA (ADSL) A DIAGNOSTIC TOOL FOR ASYMMETRIC DIGITAL SUBSCRIBER LINE LINKS

Ingeniare: Revista Chilena de Ingeniería, 2009
Se presenta el software CuLineAnalyzer, una herramienta de diagnóstico para enlaces ADSL que aprovecha las mediciones de las razones señal-ruido (SNR) de los subcanales de la técnica de transmisión DMT realizadas por las propias unidades de terminación ...
Mario Medina Carrasco, Andrés Carrasco Sternsdorff   +1 more
doaj  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

New genomic technologies and their application in pediatric care

Anales de Pediatría (English Edition)
The development of genomic technologies has transformed pediatric practice, enabling significant advances in the diagnosis of genetic diseases, 70% of which manifest during childhood.
Damià Heine Suñer, Víctor José Asensio, Laura Torres Juan   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Lecciones teórico-políticas de la coyuntura en Chile (1970-1973)

Teuken Bidikay, Revista Latinoamericana de Investigación en Organizaciones Ambiente y Sociedad, 2013
Como producto de su último trabajo investigativo, orientado a reconstruir la historia política reciente de Chile, este texto ofrece una visión crítica de aquel breve periodo de la Coyuntura (1970-1973), que significó un hito definitivo en la historia de
Hugo Zemelman
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source