Results 71 to 80 of about 684,020 (217)

PRÁCTICAS DE LECTURA Y ESCRITURA EN LA UNIVERSIDAD ¿QUÉ Y CÓMO LEEN Y ESCRIBEN LOS ESTUDIANTES DE LICENCIATURAS?

Amauta, 2013
RESUMENEl presente artículo hace parte de los resultados de un estudio etnográfi co acerca de las prácticas de lectura y escritura que se llevan a cabo en las licenciaturas de una universidad del Caribe colombiano.Los resultados que se presentan son ...
LUIS CÁRDENAS CÁRDENAS
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Lectura sin barreras: derecho, inclusión y pensamiento crítico en jóvenes con Síndrome de Down / Reading without Barriers: law, inclusion and critical thinking in young people with Down's Syndrome

Tejuelo: Didáctica de la Lengua y la Literatura
El acceso a la lectura constituye un derecho fundamental de todas las personas. En esta investigación inclusiva, realizada con jóvenes con síndrome de Down, se utiliza una metodología cualitativa y de enfoque etnográfico.
Lucía Alcántara López, Ester Trigo Ibáñez   +1 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

DE ARMARIOS Y BIBLIOTECAS: MASCULINIDAD Y TRADICIÓN LITERARIA CHILENA EN LA NARRATIVA DE ALBERTO FUGUET

Revista Chilena de Literatura, 2009
La tesis de este ensayo postula que la narrativa de Alberto Fuguet puede ser leída como un proyecto escriturario que propone una (nueva) estrategia retórica por la cual representar los desvíos del género sexual.
Cristian Opazo
doaj  

Nuevas tecnologías genómicas y su aplicación en pediatría

Anales de Pediatría
Resumen: El desarrollo de tecnologías genómicas ha transformado la práctica de la pediatría, permitiendo avances significativos en el diagnóstico de enfermedades genéticas, el 70% de las cuales comienzan en la infancia. Las variaciones genómicas, que van
Damià Heine Suñer, Víctor José Asensio, Laura Torres Juan   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source