Results 131 to 140 of about 3,623,074 (328)
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge +18 morewiley +1 more sourceA synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more sourceThe Sculpture Question [PDF]
, 2014 Paper presented, and subsequent panel discussion with: Jordan Baseman, artist and Head of Sculpture, Royal College of Art; Anna Moszynska, art historian and author, Sculpture Now; Emma Hart, artist; Jon Wood, Research Curator, Henry Moore Institute, and ...Hart, Emmacore Readers' Copyright
, 2017 This essay is part of a project intended to help reclaim copyright for readers, listeners, and viewers. A system of copyright protection makes little sense unless it is designed to encourage the use and enjoyment of the works it induces authors to create and publishers to disseminate. I argue that a clear-eyed examination of copyright's history reveals openaire +2 more sourcesAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourceAction to protect the independence and integrity of global health research
BMJ Global Health, 2019 David Sanders, Lu Gram, Benjamin Tsofa, Johanne Sundby, Tolib Mirzoev, Kristine Bærøe, Ole Frithjof Norheim, Ejemai Eboreime, Valéry Ridde, Kristine Husøy Onarheim, Emily Mendenhall, Vladimir S Gordeev, Tanya Doherty, Stephen Taylor, David Peters, Shariful Islam, Madhukar Pai, Elysée Nouvet, Francesca L Cavallaro, Shafiu Mohammed, Sassy Molyneux, Karl Blanchet, Janice E Graham, Kayvan Bozorgmehr, David McCoy, Joel Lexchin, Anna-Karin Hurtig, Asha George, Rachel Chapman, Loveday Penn-Kekana, Katerini T Storeng, Dina Balabanova, Veronique Filippi, Sidsel Roalkvam, Grace Akello, Melissa Parker, Jennifer Palmer, Ibukun Abejirinde, Babatope Adebiyi, Clara Affun-Adegbulu, Jhon Álvarez Ahlgren, Ayesha Ahmad, Sameh Al-Awlaqi, Zongo Aloys, Gianna Gayle Amul, Muhammad Asaduzzaman, Akeza Awealom Asgedom, Bouchra Assarag, Nicole Atchessi, Salla Atkins, Okikiolu Badejo, Bailah Molleh, Alessandra Bazzano, Dominique P Béhague, Uli Beisel, Loubna Belaid, Sarah Bernays, Shafi Bhuiyan, Olivia Biermann, Harriet Birungi, Astrid Blystad, Oriane Bodson, Emmanuel Bonnet, Shibaji Bose, Michelle Brear, Rochelle Burgess, Jens Byskov, Séverine Carillon, Sophie Chabeda, Clare Chandler, Francis F Chikuse, Juliana Iwu Chinwe, Beniamino Cislaghi, Svea Closser, Christopher J Colvin, Jenny Cresswell, Fabiana da Cunha Saddi, Judith Daire, Sarah Dalglish, Vincent de Brouwere, Jean-Pierre Olivier de Sardan, Thérèse Delvaux, Annabel Desgrées du Loû, Brahima A Diallo, Aïssa Diarra, Justin Dixon, Alexandre Dumont, Beth Engelbrecht, Susan Erikson, Adama Faye, Sara Fischer, Florence Fournet, Ashley M Fox, Joel Msafiri Francis, Lara Gautier, Lucy Gilson, Sarah Gimbel, Jeff Glenn, Unni Gopinathan, Christoph Gradmann, Giulia Greco, Karen Grepin, Anne Guichard, Pragya Tiwari Gupta, Viveka Guzman, Marte E S Haaland, Anna Häggblom, Amy Hagopian, Karin Hammarberg, Pascal Handschumacher, Katrina Hann, Marie Hasselberg, Natasha Howard, Sameera Hussain, Eleanor Hutchinson, Ezirim Idoteyin, Jennifer J Infanti, Rachel Irwin, Taufique Joarder, Preethi John, Ermel Johnson, Mira Johri, Judith Justice, Charles Kaboré, Kadidiatou Kadio, Matthieu Kamwa, Ann H Kelly, Nora Kenworthy, Sonja Kittelsen, Maren Olene Kloster, Emily Kocsis, Pratap Kumar, Arush Lal, Isabelle Lange, Heather Lanthorn, Frederic Le Marcis, Shelley Lees, Ann Louise Lie, Gojjam Limenih, Isabel Litwin-Davies, Charles Clarke Lodda, Knut Lönnroth, John Manton, Anatole Manzi, Mehr Manzoor, Robert Marten, Mitsuaki Matsui, Allan Mbewe, Esther Mc Sween-Cadieux, Linsey McGoey, Desmond McNeill, Claudio A Méndez, Karen Marie Moland, Zubia Mumtaz, Susan Fairley Murray, Devaki Nambiar, Erica Nelson, Claudia Nieto-Sanchez, Francis Obare, Vincent Okungu, Marit Tolo Østebø, Fatoumata Ouattara, Sachiko Ozawa, Ligia Paina, Rakesh Parashar, Elisabeth Paul, Koen Peeters, Cédric Pennetier, James Pfeiffer, Hanneke Pot, N S Prashanth, Robyn Preston, Antoine de Bengy Puyvallee, Annisa Rahmalia, Simon Reid-Henry, Daniela C Rodríguez, Maya Ronse, Emma Sacks, Oumar Mallé Samb, Eric Sarriot, Inger Brummenæs Scheel, Thomas Schwarz, Kerry Scott, Janet Seeley, Nadine Seward, Geordan Shannon, Jessica Shearer, Katharine Shelley, Kenneth Sherr, Jeremey Shiffman, Frédéric Simard, Neha S Singh, Werner Soors, Rusla Anne Springer, Adrienne Strong, Moses Tetui, Stephanie M Topp, Anne-Marie Turcotte-Tremblay, Chi-Chi Undie, Sara Van Belle, Godelieve Van Heteren, André Janse van Rensburg, Veena Sriram, Sridhar Venkatapuram, Bradley H Wagenaar, Lauren Wallace, David R Walugembe, Oghenebrume Wariri, Alan OBE Whiteside, Bereket Yakob, Scholastica Zakayo, Tony Zitti, Anthony Zwi +212 moredoaj +1 more sourcePatient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more source
