Results 81 to 90 of about 5,935,938 (300)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Statin-induced necrotizing autoimmune myopathy: an extremely rare adverse effect from statin use
Journal of Community Hospital Internal Medicine Perspectives, 2019 Statins are widely prescribed medications to prevent cardiovascular events. While self-limited statin myopathy is relatively common, statin-induced necrotizing autoimmune myopathy (SINAM) is extremely uncommon, with incidence of two cases per million per
Priyadarshani Sharma +5 more
doaj +1 more source
Remote Sensing, 2016 It has been common practice in data assimilation to treat observation errors as uncorrelated; however, meteorological centres are beginning to use correlated inter-channel observation errors in their operational assimilation systems. In this work, we are
Joanne A. Waller +5 more
doaj +1 more source
THE IMPLEMENTATION OF TEACHING READING AT SMP NEGERI 3 BATU [PDF]
, 2006 This study concerns with the implementation of teaching reading at SMP Negeri 3 Batu. Therefore, the purposes of the study are to investigate the objective of teaching reading, the topic of teaching reading, the technique of teaching reading, the ...
MAHARANI, ITA
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Facta Universitatis. Series: Mechanical Engineering, 2014 Awareness of emerging situations in a dynamic operational environment of a robotic assistive device is an essential capability of such a cognitive system, based on its effective and efficient assessment of the prevailing situation. This allows the system
Atta Badii +7 more
doaj
Exercise Preferences Among Young Adults: Do Men and Women Want Different Things? [PDF]
, 2018 Background Young adult men are difficult to recruit and retain in lifestyle interventions. This may be in part to gender differences in exercise goals observed in men, but little is known about exercise preferences for young adults, specifically.
LaRose, Jessica Gokee, Reading, Jean M
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source