Results 71 to 80 of about 92,409 (301)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Clinical Optometry, 2022 Diamantis Almaliotis, Georgios P Athanasopoulos, Stavroula Almpanidou, Eleni P Papadopoulou, Vasileios Karampatakis Laboratory of Experimental Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, GreeceCorrespondence ...
Almaliotis D +4 more
doaj
Biomedical Papers, 2017 Aims: To present the initial results of Scharioth Macula Lens (SML) implantation. The SML is a new add-on intraocular lens designed to increase uncorrected near visual acuity (UCVA) in patients with stabilized maculopathy.
Jana Nekolova +3 more
doaj +1 more source
A brief guide to carrying out research about adult social care services for visually impaired people [PDF]
, 2011 Carrying out research about adult social care services for visually impaired people presents challenges that are not necessarily found in other fields.
Charles, Nigel
core
Baseline MNREAD Measures for Normally Sighted Subjects From Childhood to Old Age [PDF]
, 2016 Purpose: The continuous-text reading-acuity test MNREAD is designed to measure the reading performance of people with normal and low vision. This test is used to estimate maximum reading speed (MRS), critical print size (CPS), reading acuity (RA), and ...
Calabrèse, A. +8 more
core +1 more source
Reading in the presence of macular disease: a mini-review. [PDF]
, 2020 PurposeReading is vital to full participation in modern society. To millions of people suffering from macular disease that results in a central scotoma, reading is difficult and inefficient, rendering reading as the primary goal for most patients seeking
Chung, Susana TL
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Reading from a Head-Fixed Display during Walking: Adverse Effects of Gaze Stabilization Mechanisms. [PDF]
PLoS ONE, 2015 Reading performance during standing and walking was assessed for information presented on earth-fixed and head-fixed displays by determining the minimal duration during which a numerical time stimulus needed to be presented for 50% correct naming answers.
Olivier Borg +2 more
doaj +1 more source
When Computer Vision Gazes at Cognition [PDF]
, 2014 Joint attention is a core, early-developing form of social interaction. It is based on our ability to discriminate the third party objects that other people are looking at.
Gao, Tao +3 more
core +1 more source
Exploration of the functional consequences of fixational eye movements in the absence of a fovea. [PDF]
, 2020 A recent theory posits that ocular drifts of fixational eye movements serve to reformat the visual input of natural images, so that the power of the input image is equalized across a range of spatial frequencies.
Agaoglu, Mehmet N, Chung, Susana TL
core