Results 71 to 80 of about 1,838,861 (234)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Using Reading Circles to Connect Readers with Text Extensive Reading

Pacific International Journal, 2022
Extensive reading course is a critical part of cultivating English majors’ language learning ability. Its teaching quality directly impacts students’ improvement of reading ability. Combined with autonomous learning theory, this paper aims to explore the practical meaning of introducing and practicing Reading Circles in extensive reading course and ...
openaire   +1 more source

Becoming well-read or reading well?: Academic Reading Circles as an innovative and inclusive practice

, 2021
Academic Reading Circles are an innovative strategy for supporting students’ academic reading practices. Based on reading circles used in more general contexts to develop students’ engagement with reading extensively, Academic Reading Circles have been adapted to the academic context to help students engage with more complex texts in their discipline.
Marinkova, M., Leslie, A.
openaire   +2 more sources

Access to books and English reading: A virtuous circle [PDF]

English Language Teaching and Research Journal (ELTAR-J), 2019
The hypothesis explored in this paper is whether a “virtuous circle” can be established to promote English language development: providing access to interesting and comprehensible reading material, which in turn will increase reading English books, which in turn will promote English competence and in turn more reading of English books. Specifically, we
Kyung Sook Cho, Stephen Krashen
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

STUDENTS’ PERSPECTIVES ON READING CIRCLES WITH LOCAL CULTURAL NARRATIVES: EVIDENCE FROM JUNIOR HIGH SCHOOLS IN BELU [PERSPEKTIF SISWA TERHADAP LINGKARAN MEMBACA DENGAN NARASI BUDAYA LOKAL: KAJIAN PADA SEKOLAH MENENGAH PERTAMA DI BELU]

Polyglot: Jurnal Ilmiah
This study investigates junior high school students’ perceptions of reading circles using local cultural texts in Belu, Indonesia. Drawing on culturally responsive pedagogy and collaborative learning principles, the intervention involved 110 eighth ...
Maria Goreti Djehatu, Priscilla Maria Assis Hornay, Elvis Albertus Bin Toni, Maria Agustina Maia Pinto   +3 more
doaj   +1 more source

The Effects of Literature Circles on Reading Fluency, Reading

, 2020
The purpose of this research is to determine the effects of literature circles on reading comprehension and reading fluency and to reveal readers' responses in this process. The model of the study was conducted in a mixed embedded experimental design.
Tosun, DK, Dogan, B
openaire  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source