Results 141 to 150 of about 255,511 (279)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

HUBUNGAN ANTARA PENGUASAAN KOSA KATA DAN KEMAMPUAN MEMBACA PEMAHAMAN DENGAN PRESTASI BELAJAR BAHASA INDONESIA SISWA KELAS VIII DI SMP NEGERI 1 KOTA SALATIGA [PDF]

, 2013
The purpose of this study was to know the relationship between the vocabulary mastery and Indonesian learning achievement, reading comprehension ability and Indonesian learning achievement, and the vocabulary mastery ...
Mudjiman, Haris, Nurdiana, Dwi Rita, Suryani, Nunuk   +2 more
core  

The Students’ Reading Comprehension Achievement and Perception Towards the Online Reading Material

International Journal of English Education and Linguistics (IJoEEL)
The use of online reading materials to improve students’ reading comprehension achievement is highly recommended. Online reading is separate from reading printed texts since it involved reading digital content such as e-books, e-dictionaries, web pages, and online education.
Lia Agustina Agustina, Nike Angraini Angraini, Jaya Nur Iman   +2 more
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

THINK ALOUD PAIR PROBLEM SOLVING (TAPPS) STRATEGY IN TEACHING READING

Indonesian EFL Journal: Journal of ELT, Linguistics, and Literature, 2015
This research is aim to know what extent the achievement of students’ reading comprehension by using Think Aloud Pair Problem Solving (TAPPS) strategy at the tenth grade students of SMKN 3 Watampone.
Muhammad Zuhri Dj, Arman Ali
doaj   +2 more sources

How and why does phonics and comprehension skill instruction impact on spelling, reading and self-efficacy for struggling adolescent learners? : a case-study : a thesis presented in partial fulfilment of the requirements for the degree of Masters in Education (Educational Psychology) at Massey University, Albany, New Zealand [PDF]

, 2017
The ability to read and write is important to learning; there is a reciprocal relationship between reading and cognitive development, and academic achievement.
Nelson, Melanie
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

The Effectiveness of Scanning Technique in Increasing Students’ Reading Comprehension Achievement [PDF]

, 2013
 Abstract: The major objective of this research was to find out whether or not scanning technique could be used to develop students’ reading comprehension achievement significantly. The students were given four treatments.
Hasan, B. (Basturi), Rachmania, E. (Eva), Suparman, U. (Ujang)   +2 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source