Results 121 to 130 of about 3,368,697 (331)

Sviluppare Competenze per Creare Test di Comprensione della Lettura Arricchiti da Domande a Scelta Multipla

open access: yesAleph
On the timeline of the development of reading, the real revolution was marked by the rise of structural cognitivism in the 1970s, anticipating another breakthrough that would result from artificial intelligence.
Abdelhalim Melzi
doaj  

Some temporal characteristics of processing during reading. [PDF]

open access: green, 1985
George W. McConkie   +3 more
openalex   +1 more source

READABILITY LEVEL OF ENGLISH READING TEXTS USED BY\ud SIXTH GRADE STUDENT OF SDN SUKOREJO I TAMBAKREJO\ud BOJONEGORO [PDF]

open access: yes, 2007
Language is one aspect which is important in human society to share their idea, feeling,\ud or to express what they want to another. One of languages in the world is English that is\ud widely known as an International Language.
OKTAVIANI, IFA
core  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

THE USE OF AUTHENTIC TEACHING MATERIALS TO IMPROVE READING COMPREHENSION (A Classroom Action Research in SMP Muhamadiyah 8 Surakarta of the Academic Year 2008/2009) [PDF]

open access: yes, 2010
Salman Alfarisi K2202046: THE USE OF AUTHENTIC TEACHING MATERIALS TO IMPROVE READING COMPREHENSION (A Classroom Action Research in SMP Muhammadiyah 8 Surakarta of the Academic Year 2008/2009).
Alfarisi/, Salman
core  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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