Results 151 to 160 of about 808,683 (307)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The Efficacy of Listening While Reading Process on Students’ Reading Fluency: A Comprehensive Review
مجلة الآداب و العلوم الإجتماعيةA significant number of students, especially those experiencing reading difficulties, encounter challenges in developing fluent reading skills which are fundamental competencies that underlie both academic success and personal development.
ايمان رزيق, مراد تواتي
doaj
An empirical study of intermediate and advanced Chinese learners of Japanese language about reading strategies based on think-aloud protocols. [PDF]
Front PsycholSun Y, Zhang M, Tan S.
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
EFL Students’ Perceptions of Top-down and Bottom-up Reading Strategies and Reading Comprehension
, 2016 [[abstract]]Over the last few decades, researchers have given attention to the effects of reading strategies on EFL reading comprehension. Although much work has been done to date, more studies need to be conducted to understand EFL students’ perceptions
楊逸君 +3 more
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Factors Influence Reading From Screen of Arabic Textbook for Learning by Children Aged 9 to 13
The problem with e-texts are related to the way texts are displayed on a screen, with multiple and different aspects that affect legibility, making readers prefer to read a paper format rather than e-resources.
Abubaker, Azza
core +1 more source
Reading to Translate or Translating to Read? Modeling Translators' Eye Movements with Multilingual Pre-Trained Models. [PDF]
J Eye Mov ResZhang Y, Yao X, Li D.
europepmc +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source