Results 121 to 130 of about 802,432 (313)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
De Biblioteca Erudita a Biblioteca Popular? As práticas de Leitura Pública na Biblioteca Pública Municipal do Porto (1833‑1926) [PDF]
, 2011 Reading practices in Porto became public with the decree dated July 9 by order of Pedro IV establishing the creation of the Public Library Municipal do Porto (BPMP).
Passos, Sónia
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Dropout Crisis: Promising Approaches in Prevention and Recovery [PDF]
, 2004 The number of high school age students who do not complete high school is receiving increased attention as a serious challenge facing the educational system. This is happening for several reasons.
Adria Steinberg, Cheryl Almeida
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Understanding the Demand Side of the Low-Wage Labor Market [PDF]
, 2008 Presents findings from a survey of employers on their less-skilled labor needs: who hires whom and how; with what requirements, wages, benefits, results, and factors for promotion; and what policies would help job seekers without a college ...
Gregory Acs, Pamela J. Loprest
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Biblioteca pública e educação: apontamentos sobre o papel da leitura hoje
Perspectivas em Ciência da InformaçãoEste artigo propõe algumas reflexões sobre o papel da biblioteca pública e da educação brasileiras hoje, no que se refere à formação de leitores. Essa é uma questão que continua atual e relevante, tendo em vista duas realidades de difícil interrelação: a
Maria da Conceição Carvalho
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source