Results 71 to 80 of about 9,132 (172)

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Medical Students' Perceptions and Attitudes Toward English as a Medium of Instruction at the Faculty of Medicine and Pharmacy of Rabat: Cross-Sectional Study. [PDF]

JMIR Form Res
Maaroufi I, Razine R, Zeghari Z, Zeddari I, Laayadi D, Obtel M, Belayachi J, Abouqal R.   +7 more
europepmc   +1 more source

Non‐Covalent Reversibly Photoconvertible Fluorescent Tags for Wash‐Free Protein Labeling

Advanced Science, EarlyView.
FAST proteins combined with one or two fluorogens undergo reversible fluorescence switching or photoconversion through photoisomerization. At low fluorogen concentration and high light intensity, they act as negative or positive photoswitchers and photoconvertible tags, which are promising for discriminating FAST variants.
Mrinal Mandal, Yuriy Shpinov, Aliénor Lahlou, Fivos Pham, Lina El Hajji, Ian Coghill, Eve Laureau, Marie‐Aude Plamont, Franck Perez, Thomas Le Saux, Isabelle Aujard, Arnaud Gautier, Ludovic Jullien   +12 more
wiley   +1 more source

Development of an algorithm to identify pelvic inflammatory diseases using regional electronic hospital records: first step to assess the burden of <i>Chlamydia trachomatis</i> infections. [PDF]

BMJ Open
Quentin E, Escolano S, Verdoux M, Martel P, Fauconnier A, Delarocque-Astagneau E, Thiébaut ACM.   +6 more
europepmc   +1 more source

Ultrafast Micrometric Laser Structuring of Polymer Surfaces for Highly Organized Skeletal Muscle Tissue Modeling

Advanced Science, EarlyView.
Standard cell culture supports were functionalized by laser‐structuring to generate advanced topographies tailored to skeletal muscle tissue. The physicochemical modifications of the polymeric surfaces and their interactions with cells were thoroughly investigated, confirming both safety and effectiveness in guiding muscle cell organization.
Lucas Duvert, Lorena Garcia‐Castillo, Clarissa Murru, Adrien Casanova, Daniel Ferry, Pierre Perrin, Solene Coste, Anne Bigot, Anne‐Patricia Alloncle, Frederique Magdinier, Stefano Testa   +10 more
wiley   +1 more source

Voice Signatures of Momentary Psychological Stress in Real-Life Environments: Results from the Colive Voice Study. [PDF]

Digit Biomark
Topalian N, Elbeji A, Bour C, Ayadi H, Pizzimenti M, Perchoux C, Fagherazzi G.   +6 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Pastourelle Narratives of Sexual Violence and Consent in Middle French and Middle Dutch Printed Popular Song. [PDF]

Neophilologus
de Morrée C.
europepmc   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

How do non-radiologist physicians read and use the radiology report? A French national survey. [PDF]

Insights Imaging
Kassab Y, Bailly M, Brabant S, Oppenheim C, Bernard-Tessier A, Stolowy N, Salaün H, Dejobert M, Lemoine T, Begon M, Boulouis G, Cottier JP, Lauvin MA, Daurel H, Piton AL, Khanna RK, Metrard G, Cohen C.   +17 more
europepmc   +1 more source