Results 171 to 180 of about 12,504 (200)

Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity.

ACS Medicinal Chemistry Letters, 2023
(+)-Negamycin, which is a dipeptide-like antibiotic containing a hydrazide structure, exhibits readthrough activity, resulting in the restoration of dystrophin in the mdx mouse model of Duchenne muscular dystrophy (DMD).
Noriko Omura, A. Taguchi, Tomoki Kuwahara, Keisuke Hamada, Mizuki Watanabe, Masanori Nakakuki, Sho Konno, Kentaro Takayama, A. Taniguchi, Toshifumi Nomura, S. Shuto, Yoshio Hayashi   +11 more
semanticscholar   +1 more source

Readthrough acetylcholinesterase in inflammation-associated neuropathies

Life Sciences, 2007
The cholinergic control over inflammatory reactions calls for deciphering the corresponding protein partners. An example is blood-nerve barrier disruption allowing penetration of inflammatory factors, which is notably involved in various neuropathies due to yet unknown molecular mechanism(s). In rats, lipopolysaccharide (LPS) administration followed by
Amir, Dori, Gal, Ifergane, Tal, Saar-Levy, Marina, Bersudsky, Inbal, Mor, Hermona, Soreq, Itzhak, Wirguin   +6 more
openaire   +2 more sources

Serum starvation enhances nonsense mutation readthrough

Journal of Molecular Medicine, 2019
Of all genetic mutations causing human disease, premature termination codons (PTCs) that result from splicing defaults, insertions, deletions, and point mutations comprise around 30%. From these mutations, around 11% are a substitution of a single nucleotide that change a codon into a premature termination codon. These types of mutations affect several
Amnon, Wittenstein, Michal, Caspi, Yifat, David, Yamit, Shorer, Prathamesh T, Nadar-Ponniah, Rina, Rosin-Arbesfeld   +5 more
openaire   +2 more sources

Developing DMD therapeutics: a review of the effectiveness of small molecules, stop-codon readthrough, dystrophin gene replacement, and exon-skipping therapies

Expert Opinion on Investigational Drugs, 2021
Introduction Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by mutations in the dystrophin (DMD) gene. Most patients die from respiratory failure or cardiomyopathy.
O. Sheikh, T. Yokota
semanticscholar   +1 more source

Comprehensive Detection of Pseudogenes Transcribed by Readthrough

2021
Transcription termination is a critical stage for the production of legitimate mRNAs, and consequently functional proteins. However, the transcription machinery can ignore the stop signs and continue elongating beyond gene boundaries, invading downstream neighboring genes.
Rui, Pinto, Daniel, Sobral, Ana Rita, Grosso   +2 more
openaire   +2 more sources

Cancer syndromes and therapy by stop-codon readthrough

Trends in Molecular Medicine, 2012
Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as aminoglycosides and PTC124 have exhibited promising ...
Renata Bordeira-Carriço, Ana Paula Pêgo, Carla Oliveira   +2 more
exaly   +4 more sources

Nonsense readthrough therapy for Duchenne muscular dystrophy

Rinsho Shinkeigaku, 2014
Duchenne muscular dystrophy (DMD) is the most common form of inherited muscle disease and is characterized by progressive muscle wasting ultimately resulting in death of the patients in their twenties. DMD is characterized by a deficiency of the muscle dystrophin as a result of mutations in the dystrophin gene. Currently, no effective treatment for DMD
openaire   +2 more sources

Translational readthrough induction of pathogenic nonsense mutations

European Journal of Medical Genetics, 2006
The treatment of genetic disorders is one of the biggest challenges lying ahead of modern medicine. While major advancements have been made in gene therapy, it is still far from achieving clinical success. However, other potential methods for treating single gene related diseases have also emerged recently.
openaire   +2 more sources

Readthrough Acetylcholinesterase: A Multifaceted Inducer of Stress Reactions

Journal of Molecular Neuroscience, 2006
Stress insults induce hyperexcitation of cholinergic circuits, both peripherally in the sympathetic pathway (Tracey, 2002) and at the central nervous system (CNS) (Sapolsky, 1996). This reaction can serve to ensure survival but might also entail a risk to the hyperactivated neurons.
Gabriel, Zimmerman, Hermona, Soreq
openaire   +2 more sources

Programmed Readthrough of Translational Termination Codons

1997
If alternative decoding events occur only during a translational pause, then any translational pause of sufficient duration could cause an aberrant event to occur. Of course, all translational pauses do not since much more is required than simply a translational pause.
openaire   +1 more source