Results 161 to 170 of about 12,504 (200)

Barriers to the Pharmacologic Rescue of W1282X CFTR. [PDF]

Biochemistry
Manfredi C, Rab A, Joshi D, Winters AG, Jackson JJ, Molina S, Koval M, Khazanov N, Jacobson M, Oliver K, Senderowitz H, Sorscher EJ, Hong JS.   +12 more
europepmc   +1 more source

Response to Suresh et al. [PDF]

EMBO J
Singh A, Manjunath LE, Akhtar MN, Ghosh J, Eswarappa SM.   +4 more
europepmc   +1 more source

Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases. [PDF]

FEBS J
Liu J, Nagy N, Ayala-Torres CM, Masucci MG.   +3 more
europepmc   +1 more source

Nonsense Mutations in Rare and Ultra-Rare Human Disorders: An Overview. [PDF]

IUBMB Life
Vitale E, Ricci D, Corrao F, Fiduccia I, Cruciata I, Carollo PS, Branchini A, Lentini L, Pibiri I.   +8 more
europepmc   +1 more source

Canonical transcription termination mechanisms explain a minority of operons in cyanobacteria

Cascino JA, Dierksheide KJ, Vishwakarma RK, Yuzenkova Y, Babitzke P, Murakami KS, Li G.   +6 more
europepmc   +1 more source

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Mammalian proteome expansion by stop codon readthrough

WIREs RNA, 2022
Recognition of a stop codon by translation machinery as a sense codon results in translational readthrough instead of termination. This recoding process, termed stop codon readthrough (SCR) or translational readthrough, is found in all domains of life ...
Lekha E. Manjunath, Anumeha Singh, Saubhik Som, S. Eswarappa   +3 more
semanticscholar   +3 more sources

Therapeutics Based on Stop Codon Readthrough [PDF]

Annual Review of Genomics and Human Genetics, 2014
Nonsense suppression therapy encompasses approaches aimed at suppressing translation termination at in-frame premature termination codons (PTCs, also known as nonsense mutations) to restore deficient protein function. In this review, we examine the current status of PTC suppression as a therapy for genetic diseases caused by nonsense mutations.
Kim M Keeling, Xiaojiao Xue, David M Bedwell   +2 more
exaly   +3 more sources

Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax [PDF]

Cell, 2014
Translational readthrough, observed primarily in less complex organisms from viruses to Drosophila, expands the proteome by translating select transcripts beyond the canonical stop codon. Here, we show that vascular endothelial growth factor A (VEGFA) mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating ...
Sandeepa M Eswarappa, Alka A Potdar, Yi Fan   +2 more
exaly   +3 more sources

Evolutionary Dynamics of Abundant Stop Codon Readthrough [PDF]

Molecular Biology and Evolution, 2016
Translational stop codon readthrough emerged as a major regulatory mechanism affecting hundreds of genes in animal genomes, based on recent comparative genomics and ribosomal profiling evidence, but its evolutionary properties remain unknown. Here, we leverage comparative genomic evidence across 21 Anopheles mosquitoes to systematically annotate ...
Irwin Jungreis, Robert M Waterhouse, Michael F Lin   +2 more
exaly   +6 more sources

Factors Affecting Readthrough of Natural Versus Premature Termination Codons.

Advances in Experimental Medicine and Biology, 2023
Nonsense mutations occur within the open-reading frame of a gene resulting in a premature termination codon (PTC). PTC-containing mRNAs can either be degeraded or cause premature translation termination producing a truncated protein that can be either nonfunctional or toxic.
Avigail Beryozkin, Kerstin Nagel-Wolfum, E. Banin, D. Sharon   +3 more
semanticscholar   +3 more sources