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Evolutionary Dynamics of Abundant Stop Codon Readthrough. [PDF]
Molecular Biology and Evolution, 2016 Translational stop codon readthrough emerged as a major regulatory mechanism affecting hundreds of genes in animal genomes, based on recent comparative genomics and ribosomal profiling evidence, but its evolutionary properties remain unknown.
Manolis Kellis +2 more
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Translational readthrough in Tobacco necrosis virus-D [PDF]
Virology, 2014 The plus-strand RNA genome of Tobacco necrosis virus-D (TNV-D) expresses its polymerase via translational readthrough. The RNA signals involved in this readthrough process were characterized in vitro using a wheat germ extract translation system and in ...
K Andrew White, Beth L Nicholson
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Readthrough compounds for nonsense mutations: bridging the translational gap [PDF]
Trends in Molecular Medicine, 2023 Approximately 10% of all pathological mutations are nonsense mutations that are responsible for several severe genetic diseases for which no treatment regimens are currently available.
Jeffrey Beekman
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Comprehensive Detection of Pseudogenes Transcribed by Readthrough
2021Transcription termination is a critical stage for the production of legitimate mRNAs, and consequently functional proteins. However, the transcription machinery can ignore the stop signs and continue elongating beyond gene boundaries, invading downstream neighboring genes.
Rui, Pinto +2 more
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Mammalian proteome expansion by stop codon readthrough
WIREs RNA, 2022AbstractRecognition of a stop codon by translation machinery as a sense codon results in translational readthrough instead of termination. This recoding process, termed stop codon readthrough (SCR) or translational readthrough, is found in all domains of life including mammals.
Lekha E. Manjunath +3 more
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Readthrough acetylcholinesterase in inflammation-associated neuropathies
Life Sciences, 2007The cholinergic control over inflammatory reactions calls for deciphering the corresponding protein partners. An example is blood-nerve barrier disruption allowing penetration of inflammatory factors, which is notably involved in various neuropathies due to yet unknown molecular mechanism(s). In rats, lipopolysaccharide (LPS) administration followed by
Amir, Dori +6 more
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A reporter system for translational readthrough of stop codons in human cells [PDF]
FEBS Open Bio, 2012 Agents to induce readthrough of premature termination codons (PTCs) are useful research tools and potential therapeutics. Reporters used to detect PTC readthrough are gene-specific and thus are not suited to for general assessment of readthrough activity
Daniel C. Liebler +2 more
exaly +2 more sources
Serum starvation enhances nonsense mutation readthrough
Journal of Molecular Medicine, 2019Of all genetic mutations causing human disease, premature termination codons (PTCs) that result from splicing defaults, insertions, deletions, and point mutations comprise around 30%. From these mutations, around 11% are a substitution of a single nucleotide that change a codon into a premature termination codon. These types of mutations affect several
Amnon, Wittenstein +5 more
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Stop is not the end: Physiological implications of translational readthrough
Journal of Theoretical Biology, 1988The translational readthrough mechanism permits the occasional misreading of termination codons by normal charged tRNAs causing extended translation beyond the stop signal. In both prokaryotes and eukaryotes translational readthrough is involved in the regulation of gene expression, as for example in the synthesis of the enzyme reverse transcriptase of
H, Engelberg-Kulka +1 more
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Influence of codon context on UGA suppression and readthrough
Journal of Molecular Biology, 1992We studied the influence of the codon context on UGA suppression by a suppressor tRNA and on UGA readthrough by a normal tRNA in Escherichia coli. This was done by a series of constructs where only the immediate context of the TGA codon was varied by only one nucleotide at a time.
J, Kopelowitz +4 more
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