Results 1 to 10 of about 108,274 (213)
Evaluation of the effect of administration of Tadalafil on Gentamicin-induced nephrotoxicity in rats [PDF]
Egyptian Journal of Medical Research, 2022 Background: Gentamicin (GNT) is a highly effective aminoglycoside antibiotic that is commonly used to treat life-threatening bacterial infections.
Ekhlas Mohammed +3 more
doaj +1 more source
The prevalence and distribution of aminoglycoside resistance genes
Biosafety and Health, 2023 Highlights • The article displayed the global resistance status of aminoglycoside antibiotics.• The prevalence of antibiotic-resistance genes in various bacterial species based on the systematic review has been described.• The article showed the ...
Yuan Zhang +10 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 After the first aminoglycoside antibiotic streptomycin being applied in clinical practice in the mid-1940s, aminoglycoside antibiotics (AGAs) are widely used to treat clinical bacterial infections and bacterial resistance to AGAs is increasing.
Nuoyan Wang +4 more
semanticscholar +1 more source
Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions
Pharmaceuticals, 2023 Plazomicin is a recent U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at
David Ngo +8 more
doaj +1 more source
A mini-review: environmental and metabolic factors affecting aminoglycoside efficacy
World Journal of Microbiology & Biotechnology, 2022 Following the discovery of streptomycin from Streptomyces griseus in the 1940s by Selman Waksman and colleagues, aminoglycosides were first used to treat tuberculosis and then numerous derivatives have since been used to combat a wide variety of ...
Calum M. Webster, Mark Shepherd
semanticscholar +1 more source
Aminoglycoside Antibiotics Inhibit Phage Infection by Blocking an Early Step of the Infection Cycle
bioRxiv, 2021 Predation by phages is a major driver of bacterial evolution. As a result, elucidating antiphage strategies is crucial from both fundamental and therapeutic standpoints.
Larissa Kever +10 more
semanticscholar +1 more source
Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough
Frontiers in Pharmacology, 2022 BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high risk of breast and
Renata B. V. Abreu +10 more
doaj +1 more source
Translation error clusters induced by aminoglycoside antibiotics
Nature Communications, 2021 Aminoglycoside antibiotics target the ribosome and induce mistranslation, yet which translation errors induce bacterial cell death is unclear. The analysis of cellular proteins by quantitative mass spectrometry shows that bactericidal aminoglycosides ...
Ingo Wohlgemuth +6 more
semanticscholar +1 more source
Host Polyunsaturated Fatty Acids Potentiate Aminoglycoside Killing of Staphylococcus aureus
Microbiology Spectrum, 2022 Aminoglycoside antibiotics rely on the proton motive force to enter the bacterial cell, and facultative anaerobes like Staphylococcus aureus can shift energy generation from respiration to fermentation, becoming tolerant of aminoglycosides.
William N. Beavers +4 more
doaj +1 more source
Ototoxicity of Non-aminoglycoside Antibiotics
Frontiers in Neurology, 2021 It is well-known that aminoglycoside antibiotics can cause significant hearing loss and vestibular deficits that have been described in animal studies and in clinical reports.
L. Rybak, V. Ramkumar, D. Mukherjea
semanticscholar +1 more source