Results 1 to 10 of about 69,478 (239)
Evaluation of the effect of administration of Tadalafil on Gentamicin-induced nephrotoxicity in rats [PDF]
Egyptian Journal of Medical Research, 2022 Background: Gentamicin (GNT) is a highly effective aminoglycoside antibiotic that is commonly used to treat life-threatening bacterial infections.
Ekhlas Mohammed +3 more
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Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions
Pharmaceuticals, 2023 Plazomicin is a recent U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at
David Ngo +8 more
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Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough
Frontiers in Pharmacology, 2022 BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high risk of breast and
Renata B. V. Abreu +10 more
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Host Polyunsaturated Fatty Acids Potentiate Aminoglycoside Killing of Staphylococcus aureus
Microbiology Spectrum, 2022 Aminoglycoside antibiotics rely on the proton motive force to enter the bacterial cell, and facultative anaerobes like Staphylococcus aureus can shift energy generation from respiration to fermentation, becoming tolerant of aminoglycosides.
William N. Beavers +4 more
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High-level resistance to aminoglycoside, vancomycin, and linezolid in enterococci strains [PDF]
Journal of Microbiology and Infectious Diseases, 2013 Objective: This study aimed to identify antibiotic susceptibility rates of enterococcal strains, and to compare the highlevelresistance to aminoglycosides (HLAR) in vancomycin-sensitive enterococcal species (VSE) and vancomycin-resistantenterococcal ...
Gülçin Baldır +6 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Antimicrobial resistance is a critical public health issue that requires a thorough understanding of the factors that influence the selection and spread of antibiotic-resistant bacteria.
Raphaël Charron +9 more
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Frontiers in Microbiology, 2022 IntroductionGentamicin is a conventional antibiotic in clinic. However, with the wide use of antibiotics, gentamicin-resistant Escherichia coli (E. coli) is an ever-increasing problem that causes infection in both humans and animals.
Yue-tao Chen +5 more
doaj +1 more source
Transcriptomic characterization of dying hair cells in the avian cochlea
Cell Reports, 2021 Summary: Sensory hair cells are prone to apoptosis caused by various drugs including aminoglycoside antibiotics. In mammals, this vulnerability results in permanent hearing loss because lost hair cells are not regenerated.
Nesrine Benkafadar +5 more
doaj +1 more source
Evaluation of Amikacin Pharmacokinetics in Critically Ill Patients with Intra-abdominal Sepsis [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Although the current widespread use of amikacin is in intra-abdominal sepsis treatment, its pharmacokinetic changes in the present setting are not yet well known.
Bita Shahrami +8 more
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Glomerular Filtration Rate Changes in Neonates with Sepsis Treated with Amikacin and Cefotaxime
Journal of Mazandaran University of Medical Sciences, 2022 Background and purpose: Aminoglycosides (AG) such as Amikacin that are widely used to prevent and treat infections in neonates have nephrotoxic effects.
Fatemeh-Sadat Tabatabaei +2 more
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