Results 41 to 50 of about 145,462 (315)
Design, Synthesis, and Bioassay of 2′-Modified Kanamycin A
Molecules, 2022 Chemical modification of old drugs is an important way to obtain new ones, and it has been widely used in developing new aminoglycoside antibiotics.
Ribai Yan +3 more
doaj +1 more source
Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]
, 2015 The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core +1 more source
An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations
Frontiers in Genetics, 2015 Several homoplasmic pathologic mutations in mitochondrial DNA, such as those causing Leber hereditary optic neuropathy or non-syndromic hearing loss, show incomplete penetrance. Therefore, other elements must modify their pathogenicity.
Sonia eEmperador +16 more
doaj +1 more source
Chemosensors, 2021 Aminoglycoside (AMG) antibiotics are being applied to treat infections caused by Gram-negative bacteria, mainly in livestock, and are prescribed only in severe cases because of their adverse impacts on human health and the environment.
Surendra Krushna Shinde +7 more
doaj +1 more source
Kidney International, 1980 Nephrotoxicity has been recognized as a major complication of aminoglycoside antibiotics for many years. During the past 6 to 8 years, this problem has attracted the attention and interest of a number of investigators, resulting in the generation of a large body of experimental data that has greatly expanded our understanding of the pathogenesis of ...
Kaloyanides, George J. +1 more
openaire +2 more sources
Importance of site of infection and antibiotic selection in the treatment of carbapenem-resistant Pseudomonas aeruginosa sepsis [PDF]
, 2018 In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95 ...
Britt, Nicholas S +6 more
core +2 more sources
mBio, 2020 Bacterial persisters exhibit noninherited antibiotic tolerance and are linked to the recalcitrance of bacterial infections. It is very urgent but also challenging to develop antipersister strategies.
Yanna Zhao +8 more
doaj +1 more source
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.
Cold Spring Harbor Perspectives in Medicine, 2018 Ototoxicity refers to damage of inner ear structures (i.e., the cochlea and vestibule) and their function (hearing and balance) following exposure to specific in-hospital medications (i.e., aminoglycoside antibiotics, platinum-based drugs), as well as a ...
C. Kros, P. Steyger
semanticscholar +1 more source
Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]
, 2017 In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De +2 more
core +1 more source
Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide-Treated Mice
Frontiers in Cellular Neuroscience, 2018 The cell-penetrating peptide GV1001 has been investigated as an anticancer agent and recently demonstrated anti-oxidant and anti-inflammatory effects. It has shown a protective effect on a kanamycin (KM)-induced ototoxicity mouse model.
Shin Hye Kim +4 more
doaj +1 more source