Results 61 to 70 of about 145,462 (315)

In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii

Journal of Antimicrobial Chemotherapy, 2019
Objectives Widespread antimicrobial resistance often limits the availability of therapeutic options to only a few last-resort drugs that are themselves challenged by emerging resistance and adverse side effects.
M. Juhas, Emma Widlake, J. Teo, D. Huseby, J. Tyrrell, Y. Polikanov, O. Ercan, A. Petersson, Sha Cao, A. Aboklaish, Anna Rominski, D. Crich, E. Böttger, T. Walsh, D. Hughes, S. Hobbie   +15 more
semanticscholar   +1 more source

Whole-Genome Sequencing and Concordance Between Antimicrobial Susceptibility Genotypes and Phenotypes of Bacterial Isolates Associated with Bovine Respiratory Disease. [PDF]

, 2017
Extended laboratory culture and antimicrobial susceptibility testing timelines hinder rapid species identification and susceptibility profiling of bacterial pathogens associated with bovine respiratory disease, the most prevalent cause of cattle ...
Abdo, Zaid, Aly, Sharif S, Belk, Keith, Blanchard, Patricia C, Davis, Jessica H, Lehenbauer, Terry W, Miller, Michael R, Morley, Paul, Noyes, Noelle, O'Rourke, Sean M, Owen, Joseph R, Prince, Daniel J, Van Eenennaam, Alison L, Young, Amy E   +13 more
core   +2 more sources

Chemical Induction of Aminoglycoside Uptake Overcomes Antibiotic Tolerance and Resistance in Staphylococcus aureus.

Cell Chemical Biology, 2019
Aminoglycoside antibiotics require proton motive force (PMF) for bacterial internalization. In non-respiring populations, PMF drops below the level required for drug influx, limiting the utility of aminoglycosides against strict and facultative anaerobes.
Lauren C Radlinski, Sarah E. Rowe, Robert Brzozowski, Alec D. Wilkinson, Rennica Huang, P. Eswara, Brian P. Conlon   +6 more
semanticscholar   +1 more source

The microbiologist’s guide to membrane potential dynamics [PDF]

, 2020
All cellular membranes have the functionality of generating and maintaining the gradients of electrical and electrochemical potentials. Such potentials were generally thought to be an essential but homeostatic contributor to complex bacterial behaviors ...
Asally, Munehiro, Benarroch, Jonatan M.
core   +1 more source

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Plazomicin: A Next‐Generation Aminoglycoside

Pharmacotherapy, 2019
Plazomicin is a novel aminoglycoside antibiotic that binds to the bacterial 30S ribosomal subunit, thus inhibiting protein synthesis in a concentration‐dependent manner.
Kristy M. Shaeer, M. Zmarlicka, E. Chahine, N. Piccicacco, Jonathan C. Cho   +4 more
semanticscholar   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Identification and Characterization of a Novel Chromosomal Aminoglycoside 2′-N-Acetyltransferase, AAC(2′)-If, From an Isolate of a Novel Providencia Species, Providencia wenzhouensis R33

Frontiers in Microbiology, 2021
Multidrug-resistant bacteria from different sources have been steadily emerging, and an increasing number of resistance mechanisms are being uncovered.
Kexin Zhou, Kexin Zhou, Kexin Zhou, Jialei Liang, Jialei Liang, Jialei Liang, Xu Dong, Xu Dong, Peiyao Zhang, Peiyao Zhang, Chunlin Feng, Chunlin Feng, Weina Shi, Weina Shi, Mengdi Gao, Mengdi Gao, Qiaoling Li, Qiaoling Li, Qiaoling Li, Xueya Zhang, Xueya Zhang, Xueya Zhang, Junwan Lu, Junwan Lu, Xi Lin, Xi Lin, Kewei Li, Kewei Li, Hailin Zhang, Hailin Zhang, Mei Zhu, Qiyu Bao, Qiyu Bao, Qiyu Bao   +33 more
doaj   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Prevalence of Antibiotic Resistome in Ready-to-Eat Salad [PDF]

, 2020
Ready-to-eat salad harbors microorganisms that may carry various antibiotic resistance genes (ARGs). However, few studies have focused on the prevalence of ARGs on salad, thus underestimating the risk of ARGs transferring from salad to consumers. In this
Giles, Madeline, Neilson, Roy, Wei, Meng-Yun, Yang, Xiao-Ru, Zhang, Qi, Zheng, Fei, Zhou, Shu-Yi-Dan, Zhu, Yong-Guan   +7 more
core   +2 more sources