Results 71 to 80 of about 69,478 (239)
Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions
Sensory Neuroscience, EarlyView.ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang +7 more
wiley +1 more source
Progress On Sensorineural Hearing Loss: Mechanisms and Therapies
Sensory Neuroscience, EarlyView.ABSTRACT Hearing loss is the most common disabling disease among humans, which adversely affects human health. Sensorineural hearing loss (SNHL) accounting for approximately 63% of all hearing loss cases. SNHL may be classified into age‐related hearing loss (ARHL), drug‐induced hearing loss (DIHL), noise‐induced hearing loss (NIHL), and sudden ...
Yuan Zhang +9 more
wiley +1 more source
AMPKα Silencing Prevents Kanamycin‐Induced Ototoxicity in an Acute Mouse Model
Sensory Neuroscience, EarlyView.Kanamycin plus furosemide (KM + FU) treatment (acute ototoxic model) causes AMPKα activation and rapidly induces cochlear outer hair cell (OHC) loss. Silencing AMPKα1 via posterior semicircular canal injection 48 h before KM + FU treatment reduces this damage, preserving OHCs and hearing.
Shengyu Zhou +6 more
wiley +1 more source
Antibiotics, 2019 Tobramycin is an aminoglycoside-based natural antibiotic derived from Streptomyces tenebrarius, which is primarily used for Gram-negative bacterial infection treatment.
Seung-Hyun Moon +2 more
doaj +1 more source
Veterinary Record, EarlyView.Abstract Background Changing legislation regarding antimicrobial consumption (AMC) forces Flemish bovine veterinary practitioners (BVP) to rethink their business models and shift their on‐farm practices from curative to preventive. However, little is known about their current practices and opinions regarding antibiotic stewardship, mastitis treatment ...
Lien Creytens +2 more
wiley +1 more source
Drug Delivery, 2017 Aminoglycoside-induced hearing loss stems from damage or loss of mechanosensory hair cells in the inner ear. Intrinsic mitochondrial cell death pathway plays a key role in that cellular dysfunction for which no proven effective therapies against oto ...
Xiao Kuang +5 more
doaj +1 more source
A few antibiotics can represent the total hospital antibiotic consumption
BMC Infectious Diseases, 2018 Background Appropriate antibiotic use has become an important issue. However, collecting data on the use of all antibiotics in a hospital is difficult without an advanced computerized system and dedicated staff. This paper examines if 1–3 antibiotics can
Bongyoung Kim +4 more
doaj +1 more source
Veterinary Record, EarlyView.Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins +8 more
wiley +1 more source
Aminoglycosides: Nephrotoxicity [PDF]
Antimicrobial Agents and Chemotherapy, 1999 Mingeot-Leclercq, Marie-Paule +1 more
openaire +3 more sources
Veterinary Record, EarlyView.Abstract Background Gram‐negative ESKAPE organisms are an emerging threat in veterinary medicine that also have zoonotic potential. However, little is known about the prevalence and risks of these organisms in pet food. We present the incidental finding of gram‐negative ESKAPE organisms within samples of raw meat diets for dogs in the United Kingdom ...
Genever Morgan +5 more
wiley +1 more source