Results 91 to 100 of about 145,462 (315)
British Journal of Clinical Pharmacology, EarlyView.Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval +6 more
wiley +1 more source
Brazilian Journal of Infectious DiseasesThe safety and efficacy of cefepime empiric monotherapy compared with standard broad-spectrum combination therapy for hospitalized adult patients with moderate to severe community-acquired bacterial infections were evaluated.
Roberto Badaró +6 more
doaj +1 more source
Frontiers in Microbiology, 2019 Aminoglycoside acetyltransferases are important determinants of resistance to aminoglycoside antibiotics in most bacterial genera. In mycobacteria, however, aminoglycoside acetyltransferases contribute only partially to aminoglycoside susceptibility ...
Fernando Sanz-García +6 more
semanticscholar +1 more source
The Interplay of Dispersion and Thermal Shock in Pseudomonas Aeruginosa Biofilms
Biotechnology and Bioengineering, EarlyView.ABSTRACT Pathological bacterial biofilms formed on medical implants pose a significant challenge in clinical settings due to their resistance to antibiotics and the host immune response. Eradication of these biofilms by thermal shock has gained increasing attention as a means of eliminating these infections.
Hossein Zare, Josiah Power, Eric Nuxoll
wiley +1 more source
Pharmacotherapy, 2018 Therapeutic drug management is regularly performed for aminoglycosides in an effort to maximize their effectiveness and safety. The ratio of maximum plasma drug concentration to minimum inhibitory concentration (Cmax/MIC) has long been regarded as the ...
Christopher M. Bland, M. Pai, T. Lodise
semanticscholar +1 more source
Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection [PDF]
, 2017 Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam ...
Helps, Alieen +5 more
core +1 more source
Chemistry – A European Journal, EarlyView.5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
Antimicrobial Agents and Chemotherapy, 2018 Increasing bacterial resistance and poor patient adherence rates limit the effectiveness of conventional antibiotic therapies for urinary tract infection (UTI).
K. Goodlet +2 more
semanticscholar +1 more source
Compounding Effects of Climate Warming and Antibiotic Resistance. [PDF]
, 2020 Bacteria have evolved diverse mechanisms to survive environments with antibiotics. Temperature is both a key factor that affects the survival of bacteria in the presence of antibiotics and an environmental trait that is drastically increasing due to ...
Cruz-Loya, Mauricio +4 more
core +1 more source
Drug Critical Limits for Urgent Physician Notification
Clinical Pharmacology &Therapeutics, EarlyView.Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang +3 more
wiley +1 more source