Results 101 to 110 of about 145,462 (315)

Effect of crocus sativus on gentamicin induced nephrotoxicity

Biological Research, 2010
Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated.
MARJAN AJAMI, SHAHRIAR EGHTESADI, HAMIDREZA PAZOKI-TOROUDI, ROUHOLLAH HABIBEY, SOLTAN AHMED EBRAHIMI   +4 more
doaj  

Bee venom ameliorates gentamicin-induced kidney injury by restoring renal aquaporins and enhancing antioxidant and anti-inflammatory activities in rats

Frontiers in Pharmacology
Introduction:Gentamicin (GM) is a frequently used aminoglycoside for managing serious illnesses; nonetheless, renal complications limit its use. Bee venom (BV) is a biological toxin that exhibits anti-inflammatory and antioxidant activities.
Doaa Abdelrahaman, Obeid Shanab, Ahmed Abdeen, Afaf Abdelkader, Khalid M. Elazab, Hagar Kouriem, Zainab M. Maher, Amal S. Abu-Almakarem, Mohamed E. Mohamed, Yasser M. Elbastawisy, Yasser M. Elbastawisy, Mohamed G. Elsehrawy, Mohamed G. Elsehrawy, Abdelnaser A. Badawy, Naglaa Mokhtar, Naglaa Mokhtar, Moaz A. Mojaddidi, Madaniah O. Zakari, Samah F. Ibrahim, Dania Abdelhady, Dania Abdelhady, Laila Mostafa   +21 more
doaj   +1 more source

In vitro Activity of Apramycin Against Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Isolates

Frontiers in Microbiology, 2020
ObjectiveThe emergence of carbapenem-resistant and hypervirulent Klebsiella pneumoniae (CR-hvKp) strains poses a significant public threat, and effective antimicrobial therapy is urgently needed.
Mingju Hao, Xiaohong Shi, Jingnan Lv, Siqiang Niu, Shiqing Cheng, Hong Du, Fangyou Yu, Yi-Wei Tang, Barry N. Kreiswirth, Haifang Zhang, Liang Chen   +10 more
doaj   +1 more source

Overcoming Aminoglycoside Enzymatic Resistance: Design of Novel Antibiotics and Inhibitors

Molecules, 2018
Resistance to aminoglycoside antibiotics has had a profound impact on clinical practice. Despite their powerful bactericidal activity, aminoglycosides were one of the first groups of antibiotics to meet the challenge of resistance.
S. G. Zárate, M. Claure, Raúl Benito-Arenas, J. Revuelta, Andrés G Santana, Á. Bastida   +5 more
semanticscholar   +1 more source

The Visual Predictive Check and Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes, Martin Bergstrand, Ron J. Keizer   +2 more
wiley   +1 more source

Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner

Nature Microbiology, 2018
Antibiotics are widely used to treat infections in humans. However, the impact of antibiotic use on host cells is understudied. Here we identify an antiviral effect of commonly used aminoglycoside antibiotics.
Smita Gopinath, Myoungjoo V. Kim, Tasfia Rakib, P. Wong, Michael van Zandt, N. Barry, T. Kaisho, A. Goodman, A. Iwasaki   +8 more
semanticscholar   +1 more source

Implantable electrochemical sensors for continuous blood monitoring

FlexMat, EarlyView.
Implantable electrochemical sensors enable direct, in situ, and continuous blood monitoring, shifting diagnosis from population‐based averages to dynamic, individualized analysis. This review systematically examines the influence of the unique blood properties on sensor design.
Kuangyi Zou, Yuanzhen Wang, Haidong Wang, Ye Zhang   +3 more
wiley   +1 more source

Aislamiento de Staphylococcus epidermidis portador de integrón clase 1 en un paciente con sepsis neonatal Isolation of Staphylococcus epidermidis strain carrier of the class one integron in a septic neonatal patient

Infectio, 2009
Objetivo. Determinar la presencia y secuencia del integrón clase I en un aislamiento clínico de Staphylococcus epidermidis proveniente de un neonato con diagnóstico de sepsis. Materiales y métodos. En una cepa de S. epidermidis, aislada de una muestra de
Gladys Pinilla, Liliana Muñoz, Ariel Ivan Ruiz, Bibiana Chavarro, Yolanda Cifuentes   +4 more
doaj  

The occurrence of ESBL-producing Escherichia coli carrying aminoglycoside resistance genes in urinary tract infections in Saudi Arabia

Annals of Clinical Microbiology and Antimicrobials, 2017
BackgroundThe infection and prevalence of extended-spectrum β-lactamases (ESBLs) is a worldwide problem, and the presence of ESBLs varies between countries.
Essam J. Alyamani, A. Khiyami, Rayan Y. Booq, Majed A. Majrashi, F. Bahwerth, E. Rechkina   +5 more
semanticscholar   +1 more source

Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection

iMetaMed, EarlyView.
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li, Ying Chen, Xi Chen, Weili Lu, Jie Liao, Jiaqi Wang, Qiwei Liu, Yanzi Chang, Zeping Xu, Yanye Tu, Yang Zhou, Jing Xue, Binbin Wang, Kang Chen, Keyun Cheng, Chunlai Zeng, Hong Li, Qing Shen   +17 more
wiley   +1 more source