Results 21 to 30 of about 73,229 (226)
Frontiers in Cellular and Infection Microbiology, 2022 Co-administration of antibiotics with synergistic effects is one method to combat carbapenem-resistant organisms. Although the synergistic effects of tigecycline combined with aminoglycosides against carbapenem-resistant Klebsiella pneumoniae (CRKP) have
Xinqian Ma +7 more
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An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations
Frontiers in Genetics, 2015 Several homoplasmic pathologic mutations in mitochondrial DNA, such as those causing Leber hereditary optic neuropathy or non-syndromic hearing loss, show incomplete penetrance. Therefore, other elements must modify their pathogenicity.
Sonia eEmperador +16 more
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Structure of the bacterial ribosome at 2 Å resolution
eLife, 2020 Using cryo-electron microscopy (cryo-EM), we determined the structure of the Escherichia coli 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous positioning of protein and RNA residues, their detailed chemical interactions, and ...
Zoe L Watson +6 more
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Design, Synthesis, and Bioassay of 2′-Modified Kanamycin A
Molecules, 2022 Chemical modification of old drugs is an important way to obtain new ones, and it has been widely used in developing new aminoglycoside antibiotics.
Ribai Yan +3 more
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Kidney International, 1980 Nephrotoxicity has been recognized as a major complication of aminoglycoside antibiotics for many years. During the past 6 to 8 years, this problem has attracted the attention and interest of a number of investigators, resulting in the generation of a large body of experimental data that has greatly expanded our understanding of the pathogenesis of ...
Kaloyanides, George J. +1 more
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Chemosensors, 2021 Aminoglycoside (AMG) antibiotics are being applied to treat infections caused by Gram-negative bacteria, mainly in livestock, and are prescribed only in severe cases because of their adverse impacts on human health and the environment.
Surendra Krushna Shinde +7 more
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mBio, 2020 Bacterial persisters exhibit noninherited antibiotic tolerance and are linked to the recalcitrance of bacterial infections. It is very urgent but also challenging to develop antipersister strategies.
Yanna Zhao +8 more
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Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide-Treated Mice
Frontiers in Cellular Neuroscience, 2018 The cell-penetrating peptide GV1001 has been investigated as an anticancer agent and recently demonstrated anti-oxidant and anti-inflammatory effects. It has shown a protective effect on a kanamycin (KM)-induced ototoxicity mouse model.
Shin Hye Kim +4 more
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AntibioticsBackground/Objectives: Gram-negative bloodstream infections (GN-BSIs) in the critically ill carry significant mortality, which is exacerbated by delays in appropriate therapy.
Joshua Eudy +7 more
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Genetic characterization of clinical Klebsiella isolates circulating in Novosibirsk
Вавиловский журнал генетики и селекции, 2021 72 clinical strains of Klebsiella spp. isolated from samples obtained from humans in Novosibirsk, Russia, were analyzed. Species identification of strains was performed using 16S rRNA and rpoB gene sequences.
A. V. Bardasheva +7 more
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