Results 21 to 30 of about 69,478 (239)

Structure of the bacterial ribosome at 2 Å resolution

eLife, 2020
Using cryo-electron microscopy (cryo-EM), we determined the structure of the Escherichia coli 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous positioning of protein and RNA residues, their detailed chemical interactions, and ...
Zoe L Watson, Fred R Ward, Raphaël Méheust, Omer Ad, Alanna Schepartz, Jillian F Banfield, Jamie HD Cate   +6 more
doaj   +1 more source

Design, Synthesis, and Bioassay of 2′-Modified Kanamycin A

Molecules, 2022
Chemical modification of old drugs is an important way to obtain new ones, and it has been widely used in developing new aminoglycoside antibiotics.
Ribai Yan, Xiaonan Li, Yuheng Liu, Xinshan Ye   +3 more
doaj   +1 more source

Histidine Functionalized Gold Nanoparticles for Screening Aminoglycosides and Nanomolar Level Detection of Streptomycin in Water, Milk, and Whey

Chemosensors, 2021
Aminoglycoside (AMG) antibiotics are being applied to treat infections caused by Gram-negative bacteria, mainly in livestock, and are prescribed only in severe cases because of their adverse impacts on human health and the environment.
Surendra Krushna Shinde, Dae-Young Kim, Rijuta Ganesh Saratale, Avinash Ashok Kadam, Ganesh Dattatraya Saratale, Asad Syed, Ali H. Bahkali, Gajanan Sampatrao Ghodake   +7 more
doaj   +1 more source

Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide-Treated Mice

Frontiers in Cellular Neuroscience, 2018
The cell-penetrating peptide GV1001 has been investigated as an anticancer agent and recently demonstrated anti-oxidant and anti-inflammatory effects. It has shown a protective effect on a kanamycin (KM)-induced ototoxicity mouse model.
Shin Hye Kim, Gaon Jung, Sangjae Kim, Ja-Won Koo, Ja-Won Koo   +4 more
doaj   +1 more source

Rapid Freezing Enables Aminoglycosides To Eradicate Bacterial Persisters via Enhancing Mechanosensitive Channel MscL-Mediated Antibiotic Uptake

mBio, 2020
Bacterial persisters exhibit noninherited antibiotic tolerance and are linked to the recalcitrance of bacterial infections. It is very urgent but also challenging to develop antipersister strategies.
Yanna Zhao, Boyan Lv, Fengqi Sun, Jiafeng Liu, Yan Wang, Yuanyuan Gao, Feng Qi, Zengyi Chang, Xinmiao Fu   +8 more
doaj   +1 more source

The Pharmacodynamics of Aminoglycosides [PDF]

Clinical Infectious Diseases, 1998
Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect. This pharmacodynamic information, along with better knowledge of the mechanisms responsible for aminoglycoside toxicity,
M K, Lacy, D P, Nicolau, C H, Nightingale, R, Quintiliani   +3 more
openaire   +2 more sources

Evaluation of Adjunctive Aminoglycoside Therapy Compared to β-Lactam Monotherapy in Critically Ill Patients with Gram-Negative Bloodstream Infections

Antibiotics
Background/Objectives: Gram-negative bloodstream infections (GN-BSIs) in the critically ill carry significant mortality, which is exacerbated by delays in appropriate therapy.
Joshua Eudy, Aaron M. Chase, Divisha Sharma, Zoheb Irshad Sulaiman, August Anderson, Ashley Huggett, Lucy Gloe, Daniel T. Anderson   +7 more
doaj   +1 more source

Genetic characterization of clinical Klebsiella isolates circulating in Novosibirsk

Вавиловский журнал генетики и селекции, 2021
72 clinical strains of Klebsiella spp. isolated from samples obtained from humans in Novosibirsk, Russia, were analyzed. Species identification of strains was performed using 16S rRNA and rpoB gene sequences.
A. V. Bardasheva, N. V. Fomenko, T. V. Kalymbetova, I. V. Babkin, S. O. Chretien, E. V. Zhirakovskaya, N. V. Tikunova, V. V. Morozova   +7 more
doaj   +1 more source

Aminoglycoside and Nephrotoxicity

Kidney and Blood Pressure Research, 1987
The effect of three aminoglycosides – gentamicin, netilmicin and amikacin – on renal acid excretion was studied in male rats treated with doses equivalent to those clinically used. The amikacin and netilmicin groups showed no important changes in the values of glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and U/P inulin ratio ...
V L, Silva, F Z, Gil, G, Nascimento, M F, Cavanal   +3 more
openaire   +2 more sources

Rationally Designing Aptamer Sequences with Reduced Affinity for Controlled Sensor Performance

Sensors, 2015
The relative ease of predicting the secondary structure of nucleic acid sequences lends itself to the design of sequences to perform desired functions.
Lauren R. Schoukroun-Barnes, Ryan J. White   +1 more
doaj   +1 more source