Results 11 to 20 of about 73,229 (226)
Glomerular Filtration Rate Changes in Neonates with Sepsis Treated with Amikacin and Cefotaxime
Journal of Mazandaran University of Medical Sciences, 2022 Background and purpose: Aminoglycosides (AG) such as Amikacin that are widely used to prevent and treat infections in neonates have nephrotoxic effects.
Fatemeh-Sadat Tabatabaei +2 more
doaj
Frontiers in Cellular Neuroscience, 2020 Aging, noise, and ototoxic drug-induced hair cell (HC) loss are the major causes of sensorineural hearing loss. Aminoglycoside antibiotics are commonly used in the clinic, but these often have ototoxic side effects due to the accumulation of oxygen-free ...
Song Gao +17 more
doaj +1 more source
Children, 2021 We aimed to determine the incidence of acute kidney injury (AKI) and longitudinal changes in SCr levels and urinary biomarkers associated with AKI and aminoglycoside (AG) medication during the first week of life of late preterm infants.
Sang-Yoon Lee +2 more
doaj +1 more source
The Pharmacodynamics of Aminoglycosides [PDF]
Clinical Infectious Diseases, 1998 Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect. This pharmacodynamic information, along with better knowledge of the mechanisms responsible for aminoglycoside toxicity,
M K, Lacy +3 more
openaire +2 more sources
Anais da Academia Brasileira de Ciências, 2018 Aminoglycosides are a class of antibiotics that play a key role in antimicrobial treatment of Multidrug resistant (MDR) Gram-negative bacilli, typically in combination with β-lactams. Ribosomal 16S RNA modification by methyltransferases (e.g. RmtG) is an
HEMANOEL PASSARELLI-ARAUJO +5 more
doaj +1 more source
Recoding of Nonsense Mutation as a Pharmacological Strategy
Biomedicines, 2023 Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. The PTC results in the production of a potentially harmful shortened polypeptide and activation of a
Gazmend Temaj +5 more
doaj +1 more source
eLife, 2020 Stop codon readthrough (SCR) occurs when the ribosome miscodes at a stop codon. Such readthrough events can be therapeutically desirable when a premature termination codon (PTC) is found in a critical gene.
Jamie R Wangen, Rachel Green
doaj +1 more source
Van Tıp Dergisi, 2021 INTRODUCTION: Aminoglycosides are used in gram-negative bacterial infection and are frequently used against Enterobacteriaceae and nonfermentative bacteria. Recently, increased resistance to aminoglycosides has been observed.
Yeliz Tanriverdi Çaycı +4 more
doaj +1 more source
Analysis of potential protective effects of caffeic acid phenethyl ester against gentamicin ototoxicity: An experimental study [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): In this study, it is aimed to investigate the potential protective effect of caffeic acid phenethyl ester (CAPE) on ototoxicity caused by gentamicin in a rat model.Materials and Methods: Thirty Wistar albino rats were divided into 3 groups.
Fuat Aydemir +3 more
doaj +1 more source
Aminoglycoside and Nephrotoxicity
Kidney and Blood Pressure Research, 1987 The effect of three aminoglycosides – gentamicin, netilmicin and amikacin – on renal acid excretion was studied in male rats treated with doses equivalent to those clinically used. The amikacin and netilmicin groups showed no important changes in the values of glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and U/P inulin ratio ...
V L, Silva +3 more
openaire +2 more sources