Results 11 to 20 of about 69,478 (239)
Frontiers in Cellular Neuroscience, 2020 Aging, noise, and ototoxic drug-induced hair cell (HC) loss are the major causes of sensorineural hearing loss. Aminoglycoside antibiotics are commonly used in the clinic, but these often have ototoxic side effects due to the accumulation of oxygen-free ...
Song Gao +17 more
doaj +1 more source
Children, 2021 We aimed to determine the incidence of acute kidney injury (AKI) and longitudinal changes in SCr levels and urinary biomarkers associated with AKI and aminoglycoside (AG) medication during the first week of life of late preterm infants.
Sang-Yoon Lee +2 more
doaj +1 more source
Anais da Academia Brasileira de Ciências, 2018 Aminoglycosides are a class of antibiotics that play a key role in antimicrobial treatment of Multidrug resistant (MDR) Gram-negative bacilli, typically in combination with β-lactams. Ribosomal 16S RNA modification by methyltransferases (e.g. RmtG) is an
HEMANOEL PASSARELLI-ARAUJO +5 more
doaj +1 more source
eLife, 2020 Stop codon readthrough (SCR) occurs when the ribosome miscodes at a stop codon. Such readthrough events can be therapeutically desirable when a premature termination codon (PTC) is found in a critical gene.
Jamie R Wangen, Rachel Green
doaj +1 more source
Recoding of Nonsense Mutation as a Pharmacological Strategy
Biomedicines, 2023 Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. The PTC results in the production of a potentially harmful shortened polypeptide and activation of a
Gazmend Temaj +5 more
doaj +1 more source
Van Tıp Dergisi, 2021 INTRODUCTION: Aminoglycosides are used in gram-negative bacterial infection and are frequently used against Enterobacteriaceae and nonfermentative bacteria. Recently, increased resistance to aminoglycosides has been observed.
Yeliz Tanriverdi Çaycı +4 more
doaj +1 more source
Analysis of potential protective effects of caffeic acid phenethyl ester against gentamicin ototoxicity: An experimental study [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): In this study, it is aimed to investigate the potential protective effect of caffeic acid phenethyl ester (CAPE) on ototoxicity caused by gentamicin in a rat model.Materials and Methods: Thirty Wistar albino rats were divided into 3 groups.
Fuat Aydemir +3 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Co-administration of antibiotics with synergistic effects is one method to combat carbapenem-resistant organisms. Although the synergistic effects of tigecycline combined with aminoglycosides against carbapenem-resistant Klebsiella pneumoniae (CRKP) have
Xinqian Ma +7 more
doaj +1 more source
Kidney International, 1980 Nephrotoxicity has been recognized as a major complication of aminoglycoside antibiotics for many years. During the past 6 to 8 years, this problem has attracted the attention and interest of a number of investigators, resulting in the generation of a large body of experimental data that has greatly expanded our understanding of the pathogenesis of ...
Kaloyanides, George J. +1 more
openaire +2 more sources
An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations
Frontiers in Genetics, 2015 Several homoplasmic pathologic mutations in mitochondrial DNA, such as those causing Leber hereditary optic neuropathy or non-syndromic hearing loss, show incomplete penetrance. Therefore, other elements must modify their pathogenicity.
Sonia eEmperador +16 more
doaj +1 more source