Overview of molecular signatures of senescence and associated resources: pros and cons
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
A practical photocatalytic strategy for radical (deuterio)difluoromethylation using imidazolium reagents. [PDF]
Sun C +11 more
europepmc +1 more source
Syntheses and Utilities of New Analytical Reagents for Potassium. I-II. II. a-Hexyl
桐栄 恭二
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Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Protocol to pinpoint oxidized and reduced cysteine residues in brown fat using differential alkylation labeling techniques. [PDF]
Oo HK +4 more
europepmc +1 more source
Rearrangement Reactions of Bromotropolones with Basic Reagents
Tetsuo Nozoe +2 more
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Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
Cost-Effective and High-Throughput LPS Detection via Microdroplet Technology in Biopharmaceuticals. [PDF]
Colombelli A +9 more
europepmc +1 more source
Metallographic etching reagents: II. For copper alloys, nickel, and the alpha alloys of nickel
H. S. Rawdon, M. G. Lorentz
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