Results 191 to 200 of about 1,325,140 (312)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

An Amphibious Bifunctional Probe for Protein Chemical Cross-Linking. [PDF]

J Am Chem Soc
Karpíšek M, Fojtík L, Fiala J, Langer V, Matoušek V, Kukačka Z, Novák P.   +6 more
europepmc   +1 more source

New reagents. IX. Fluorinating reagents. Silicon tetrafluoride as monofluorination reagent.

Journal of Synthetic Organic Chemistry, Japan, 1990
SHIMIZU, Makoto, YOSHIOKA, Hirosuke
openaire   +2 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Heat treatment of emicizumab samples - a way forward? [PDF]

Res Pract Thromb Haemost
Kimiaei A, Braf A, Antovic J.
europepmc   +1 more source

New reagents. IX. Fluorinating reagents. Fluorinating reagent: DAST.

Journal of Synthetic Organic Chemistry, Japan, 1990
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Ultra-Low-Threshold Laser Patterning of Graphene With a Modular Sulfonium Library for Programmable Work-Function Engineering. [PDF]

Adv Mater
Wang B, Jia S, Liu Z, Qin C, Yuan S, Hirsch A, Lu X, Bao L.   +7 more
europepmc   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Force-Accelerated Autocatalysis in a Knoevenagel Condensation Reaction during Ball Milling. [PDF]

J Am Chem Soc
Floyd KR, Nwoye EC, Mella L, Gonzalez PV, Felts JR, Batteas JD.   +5 more
europepmc   +1 more source