Results 91 to 100 of about 1,738,958 (224)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
, 2017 © 2016, The Natural Computing Applications Forum. Complex fuzzy sets and complex intuitionistic fuzzy sets cannot handle imprecise, indeterminate, inconsistent, and incomplete information of periodic nature.
M Ali (6099503) +1 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Fixed point theorems for set valued functions
, 1970 This dissertation considers fixed point theorems for set valued functions, F : X -> X. The first part of this dissertation extends the class of those set valued functions which induce homomorphisms h : H[lowered *] (X) H[lowered *] (X) that satisfy the ...
Wheatley, Patrick Owen
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Hull-concave set-valued functions
, 1994 A set-valued function F is called hull-concave ifF(tx + (1-t)y) ⊂ co(tF(x) + (1-t)F(y))for all x,y from the domain of F and all t∈[0,1]. It is shown that if a hull-concave set-valued function F is defined on an open convex subset D of ℝn and for ...
Papalini, Francesca +2 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Set valued measures and integral representation [PDF]
, 1996 summary:The extension theorem of bounded, weakly compact, convex set valued and weakly countably additive measures is established through a discussion of convexity, compactness and existence of selection of the set valued measures; meanwhile, a ...
Xue, Xiaoping +3 more
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