Results 81 to 90 of about 1,738,958 (224)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Simultaneous approximation of a set of bounded real functions
, 1969 The problem of simultaneous Chebyshev approximation of a set F F of uniformly bounded, real-valued functions on a compact interval I I .
H. W. McLaughlin, J. B. Diaz
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
On Lp Space Formed by Real-Valued Partial Functions
, 2010 This article is the continuation of [31]. We define the set of Lp integrable functions - the set of all partial functions whose absolute value raised to the p-th power is integrable. We show that Lp integrable functions form the Lp space.
Yasunari Shidama +5 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Inferability of Recursive Real-Valued Functions
, 1997 This paper presents a method of inductive inference of real-valued functions from given pairs of observed data of (x, h(x)), where h is a target function to be inferred.
Arikawa, Setsuo +3 more
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
MEASURABILITY OF SET-VALUED FUNCTIONS
, 1986 In the paper to the definition of measurability of set-valued functions such a a-algebra is presented by which the well-known properties of the real functions will furtheron hold, e.g. Lusin's and Egorov's theorems.
Bellay, Ágnes
core
Local Maximum Modulus Property for Polyanalytic Functions
, 2016 Let be an open subset and let be a space of functions defined on . is said to have the local maximum modulus property if: for every and for every sufficiently small domain with it holds true that where denotes the set of points at which attains strict ...
Krantz, Steven G.,, Daghighi, Abtin,
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source