Results 41 to 50 of about 1,738,958 (224)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Strong m-convexity of set-valued functions
, 2023 In this research we introduce the concept of strong m-convexity for set-valued functions defined on m-convex subsets of real linear normed spaces, a variety of properties and examples of these functions are shown, an inclusion of Jensen type is also ...
Lara, Teodoro +3 more
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Modular decomposition of the NOR-TSUM multiple-valued PLA
, 1997 A method for designing PLA-based combinational circuits by modular decomposition is presented. Main subjects are 1) Specific properties of TSUM operator, 2) MIN-TSUM and NOR-TSUM expansions with respect to the bound set, X1 of variables, 3) Realization ...
Kalganova, T +2 more
core
On the measurable dynamics of real rational functions [PDF]
, 2003 Let f be a real rational function with all critical points on the extended real axis and of even order. Then: (1) f carries no invariant line field on the Julia set unless it is doubly covered by an integral torus endomorphism (a Lattés example); and
Shen, Weixiao, Weixiao Shen
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
On the extension of set-valued set functions
, 2000 CITATION: Brink, H. E. & Maritz, P. 2000. On the Extension of Set-Valued Set Functions. Real Analysis Exchange, 26(1):261-276.The original publication is available at https://projecteuclid.orgWe extend additive set-valued set functions and normal ...
Maritz, P., Brink, H. E.
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source