Results 51 to 60 of about 1,738,958 (224)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Increase-along-rays property for vector functions [PDF]
In this paper we extend to the vector case the notion of increasing along rays function. The proposed definition is given by means of a nonlinear scalarization through the so-called oriented distance function from a point to a set.
Rocca Matteo +2 more
core
Hyperdefinable groups and modularity [PDF]
, 2011 In this thesis is presented a study of groups of the form G/G^{00}, where G is a 1-dimensional, definably compact, definably connected, definable group in a saturated real closed field M, with respect to a notion called 1-basedness. In particular G will
Penazzi, Davide
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Solving ill-posed bilevel programs [PDF]
, 2016 This paper deals with ill-posed bilevel programs, i.e., problems admitting multiple lower-level solutions for some upper-level parameters. Many publications have been devoted to the standard optimistic case of this problem, where the difficulty is ...
Zemkoho, Alain B., Alain B. Zemkoho
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Continuity of generalized convex and generalized concave set-valued functions
, 1993 The connection between continuity, lower semicontinuity, upper semicontinuity, local boundedness and uniform boundedness is investigated for two new types of set-valued functions which generalize the convex and concave set-valued functions, respectively.
Duisburg Univ. (Gesamthochschule) (Germany). Fachbereich 11 - Mathematik +1 more
core
Shannon’s Sampling Theorem for Set-Valued Functions with an Application
In this study, we defined a kind of Fourier expansion of set-valued square-integrable functions. In fact, we have seen that the classical Fourier basis also constitutes a basis for the Hilbert quasilinear space (Formula presented.) of (Formula presented.)
Halise Levent +5 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source